分别以亲水性高分子材料聚乙二醇6000 (PEG 6000),聚乙烯吡咯烷酮 (PVP K30),共聚维酮 (coPVP)作载体,以溶剂法制备利伐沙班固体分散体,并进行体外溶出研究.采用差示扫描量热法 (DSC),X-射线衍射法 (XRD)及扫描电镜法 (SEM)对制备的固体分散体进行物相鉴别.结果表明,当利 …

以聚乙二醇6000 (PEG6000),聚乙烯吡咯烷酮 (PVP k30)和共聚维酮 (coPVP)为载体,选择溶剂法、熔融法、溶剂熔融法制备利伐沙班固体分散体,并以固体分散体为基础制备胶囊。

2007年9月1日 · Solid dispersions (SDs) of dipyridamole (DIP) with a novel carrier copolyvidonum Plasdone S-630 (CoPVP) were developed by solvent evaporation method.

Solid dispersions (SDs) of dipyridamole (DIP) with a novel carrier copolyvidonum Plasdone S-630 (CoPVP) were developed by solvent evaporation method. The solid state of SDs of DIP with CoPVP (SDs CoPVP) was characterized by fourier transform infrared spectroscopy (FT-IR), differential scanning calor …

2019年2月1日 · ASDs consisting of CEL (20%), copovidone (CoPVP), and TPGS at various levels (0, 5, 10, and 20%) were prepared using spray drying. At 20% level, TPGS increased the dissolution rate and supersaturation of CEL ASDs.

与 HPMC 和 Syloid 244 FP 相比，coPVP 成为更合适的沉淀抑制剂。 随后，非下沉条件下的体外溶出研究表明，使用 coPVP 作为聚合物载体的三元系统具有更高程度的过饱和度，因为这些系统在检测条件下表现出释放的 OLN 增加高达 2 倍与纯结晶药物相比。

2020年4月1日 · These results clearly indicate the critical role of an appropriate polymer (such as CoPVP) and polymer concentration to stabilize the generated supersaturated concentrations.

For each spectrum, two integrals from bicalutamide and coPVP were generated and then scaled to integrals obtained from the reference solutions of known concentration. The spectra from the...

在最近诊断为轻度至中度 COPD 的患者中，在调整多种其他因素后，COPVP（尤其是 MRproANP）升高的值是全因死亡风险的稳健、独立的生物标志物。

2019年5月20日 · 对乙醇在碱性介质中电化学氧化的催化性能和催化机理。 结果表明,产物为单质Co与PVP的复合颗粒材料,平均. 粒径约12mm,呈球形,分散性好。 以1.0mo/LC2H、OH+1.0mol/LKOH为电解液,0.22V电位下电流密度达. 到22mMem2。 当金属离子初始浓度为20mol/L,反应温度为0℃时,制备的Co-PVP材料对乙醇的电化学氧化. chronoamperometry methods. The results showed that the obtained catalyst existed as a single matter of co.