The CPFE syndrome is a consideration in the patient with pulmonary hypertension and abnormal lung function on PFTs, especially with a mixed obstructive/restrictive abnormality. 33 CPFE also has been recognized in the lung cancer population, being present in 101 of 1,143 (8.9%) consecutive patients with lung cancer in a study by Usui et al. 34 ...

2024年1月21日 · CPFE被定义为一种综合征，一方面是因为纤维化和肺气肿的共存是这一组疾病的共同特征，监测疾病进展不能完全依靠FVC，FVC的变化通常用来评估特发 ...

Combined pulmonary fibrosis and emphysema (CPFE) is a clinicoradiologic syndrome characterized by chronic respiratory symptoms, radiologic evidence of both parenchymal fibrosis and emphysema, and gas exchange abnormalities.

2022年10月23日 · CPFE是一种综合征 (即，一组具有临床相关意义和/或主要病理意义的临床和放射学表现)，还是一个独特的疾病，目前尚无共识。 实质上，CPFE仍然相对缺乏研究，没有具体的治疗方法。 该工作组的目标是:1)描述CPFE的术语、定义、病因、特征、共病和结果;2)提供CPFE的共识定义和术语，确定它是否代表一种综合征，描述其处理方法，并确定研究重点。 方法. 该研究共识由美国胸科学会 (ATS)、欧洲呼吸学会 (ERS)、日本呼吸学会 (JRS)和拉丁美洲胸 …

CPFE is a syndrome presenting with dyspnea on exertion followed by disruptive cough and recurrent exacerbations. The disease may progress rapidly, be aggravated by pulmonary hypertension WHO group 3 and is associated with an increased risk of lung cancer. Smoking and male sex are important risk factors.

Emphysema is relatively common in patients with fibrotic interstitial lung disease (fILD), including idiopathic pulmonary fibrosis (IPF), and is designated “combined pulmonary fibrosis and emphysema” (CPFE) 1, 2. Despite its clinical significance and a number of published series 3, CPFE remains poorly understood.

2024年4月2日 · Combined pulmonary fibrosis and emphysema is a controversial and poorly defined entity. Smoking-related lung diseases can coexist and the combination of emphysema and fibrosis carries a high risk of pulmonary hypertension and a poor prognosis. Combined pulmonary fibrosis and emphysema typically occurs in male smokers 3.

2022年8月15日 · The committee proposes to identify CPFE as a syndrome, given the clustering of pulmonary fibrosis and emphysema, shared pathogenetic pathways, unique considerations related to disease progression, increased risk of complications (pulmonary hypertension, lung cancer, and/or mortality), and implications for clinical trial design.

肺纤维化合并肺气肿 (CPFE)综合征是一种不同于单纯肺气肿或肺纤维化的新型临床综合征,该病在影像学上表现为上肺的肺气肿以及下肺的肺纤维化.目前其发病原因不明,国内外缺乏统一的诊疗指南,并发症多且预后较差.因此,如何对CPFE患者进行早期识别并干预已成为呼吸科医生面对的一大难题.本文就CPFE的病因及发病机制、临床表现、辅助检查、诊断、治疗、并发症、预后等方面进行综述,以期为该病的临床诊治提供参考.

Combined pulmonary fibrosis and emphysema (CPFE), describes a medical syndrome involving both pulmonary fibrosis and emphysema. [1] [2] The combination is most commonly found in male smokers. Pulmonary function tests typically show preserved lung volume with …