These activity-based protein profiling (ABPP) methods exploit the power of chemistry to engender new tools and assays for the global analysis of enzyme activities. The enzyme activity profiles generated by ABPP constitute unique molecular portraits of cells and tissues that illuminate how metabolic and signaling networks are regulated in vivo.

Benjamin Franklin Cravatt III is a professor in the Department of Chemistry at The Scripps Research Institute in La Jolla, California. [1] Considered a co-inventor of activity-based proteomics and a substantial contributor to research on the endocannabinoid system, he is a prominent figure in the field of chemical biology.

Our research aims to address this challenge by developing and applying innovative chemical proteomic platforms, such as activity-based protein profiling, to enrich our understanding of disease-relevant proteins and to accelerate the discovery of chemical probes for these proteins.

2022年沃尔夫化学奖得主之一本杰明·克拉瓦特三世（Benjamin Cravatt III）来自久负盛名的斯克里普斯研究所化学系。 克拉瓦特的导师、斯克利普斯研究所首任所长、世界顶尖科学家协会（WLA）联合创始人理查德·乐纳（Richard Lerner）也曾在1994年获得沃尔夫化学奖。 获奖后，克拉瓦特在感言中表达了对导师的追思： “很荣幸获得沃尔夫奖。 包括我的导师理查德·乐纳在内，多位斯克里普斯的同侪都曾获得该奖项，他们是我的科学榜样。 能与他们比肩齐名，是我 …

BF Cravatt, O Prospero-Garcia, G Siuzdak, NB Gilula, SJ Henriksen, ... Science 268 (5216), 1506-1509, 1995. 787: 1995: Mechanism-based profiling of enzyme families. MJ Evans, BF Cravatt. Chemical reviews 106 (8), 3279-3301, 2006. 731: 2006: Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.

Benjamin F. Cravatt III, Ph.D. Professor and Gilula Chair of Chemical Biology. The Department of Chemistry and Skaggs Institute for Chemical Biology . The Scripps Research Institute. E-mail: [email protected]

Dr. Cravatt is a Professor in the Skaggs Institute for Chemical Biology and Chair of the Department of Chemical Physiology at Scripps Research. Cravatt obtained his undergraduate education at...

The cravat (/ krəˈvæt /) is a neckband, the forerunner of the modern tailored necktie and bow tie, originating from a style worn by members of the 17th century military unit known as the Cravats. [1] . The modern British "cravat" is called an "ascot" in American English.

Benjamin F. Cravatt III，斯克里普斯研究所（Scripps Research）教授。 2022年2月，获得2022年沃尔夫化学奖，表彰其“对理解细胞通信化学和发明化学方法以研究碳水化合物、脂质和蛋白质在此类生物过程中的作用的开创性贡献”。

Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function directly in native biological systems on a global scale. Here, we review the basic technology of ABPP, the enzyme classes addressable by this method, and the biological discoveries attributable to its application.