天津大学发表了发现了一类新型CRBN配体，在苯环与glutarimide之间用酰胺键相连。通过TR-FRET实验测试了这些化合物对CRBN的结合能力，这3个化合物（YJ1b，YJ2c，YJ2e）均表 …

2022年11月22日 · Cereblon（CRBN）是细胞中主要蛋白质处理系统的一部分。 该系统用称为泛素的分子标记靶向蛋白质，有效地标记蛋白质，以通过称为蛋白酶体的流动蛋白质分解复合物 …

FM 3-05.132 provides CBRN mission guidance to the CRD, CDD, and DRT commanders, and all CBRN personnel throughout ARSOF. This manual gives ARSOF commanders and staffs a …

Company CBRN NCO, CBRNE Response Team member, Chemical Reconnaissance Detachment member, or Decontamination and Reconnaissance Team Member

2024年10月15日 · We present the design of CRBN midi, a construct that readily expresses from E. coli with high yields as soluble, stable protein without DDB1. We benchmark CRBN midi for …

2024年12月24日 · CRBN (Cereblon) is a Protein Coding gene. Diseases associated with CRBN include Intellectual Developmental Disorder, Autosomal Recessive 2 and Autosomal …

2024年7月18日 · Chemical, Biological, Radiological, and Nuclear (CBRN) Noncommissioned Officers lead CBRN reconnaissance/decontamination operations at all levels, manage …

The Special Forces Chemical Reconnaissance Detachment or CRD is the primary asset for advanced reconnaissance sample collection support in a Chemical Biological Reconnaissance …

2021年9月6日 · Binding of IMiDs to Cereblon (CRBN), the substrate receptor of the CRL4 CRBN E3 ubiquitin ligase, induces cancer cell death by targeting key neo-substrates for degradation. …

Cereblon (CRBN) is a substrate recognition protein in the E3-ligase ubiquitin complex. The binding target of CRBN varies according to tissues and cells, and the protein regulates various …