The novel mechanism of lenalidomide activity - PMC
Lenalidomide acts by a novel drug mechanism—modulation of the substrate specificity of the CRL4 CRBN E3 ubiquitin ligase. In multiple myeloma, lenalidomide induces the ubiquitination …
CRBN配体的作用和最新进展 - 知乎 - 知乎专栏
它们被称为cereblon（CRBN）E3连接酶调节剂（CELMoD）或者免疫调节药物（IMiDs），与CRBN结合，CRBN与 DDB1 (damaged DNA binding protein 1)、Cul4A (Cullin 4A)、ROC1 …
The E3 ligase adapter cereblon targets the C-terminal cyclic imide ...
2022年10月19日 · The ubiquitin E3 ligase substrate adapter cereblon (CRBN) is a target of thalidomide and lenalidomide1, therapeutic agents used in the treatment of haematopoietic …
Cereblon: A Protein Crucial to the Multiple Functions of ...
CRBN helps the E3 ubiquitin ligase complex target ion channels for ubiquitination and therefore maintains the ion balance and reduces the incidence of ion channel disease. CRBN is a …
The E3 ubiquitin ligase component, Cereblon, is an ... - Nature
2021年9月6日 · We injected either crbn mRNA 53, crbn morpholino (MO) 35, or three distinct guide RNA (sgRNA) sequences targeting crbn along with dCas9 mRNA (CRISPRi), into …
Developing next generation immunomodulatory drugs and their ...
IMiD/CELMoD compounds bind CRBN, a substrate receptor of the Cul4A/DDB1/Roc1 (Cul4A CRBN) E3 ligase complex, and trigger recruitment, polyubiquitination and subsequent …
Targeting cereblon in hematologic malignancies - ScienceDirect
2023年1月1日 · The protein cereblon (CRBN) is a substrate receptor of the cullin 4-really interesting new gene (RING) E3 ubiquitin ligase complex CRL4 CRBN. Targeting CRBN …
Discovery of Highly Potent CRBN Ligands and Insight into Their …
2023年3月1日 · Cereblon (CRBN) is a substrate receptor of E3 ubiquitin ligase as well as the target of thalidomide and lenalidomide, plays a vital role in endogenous protein degradation. In …
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN …
2016年7月14日 · Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4 (CRBN) E3 ubiquitin ligase. Here we report the identification …
The novel mechanism of lenalidomide activity
2015年11月19日 · Lenalidomide acts by a novel drug mechanism—modulation of the substrate specificity of the CRL4 CRBN E3 ubiquitin ligase. In multiple myeloma, lenalidomide induces …
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