Cre-Lox recombination is a site-specific recombinase technology, used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus.

Unlock the power of the Cre/lox system for tissue-specific, inducible knockouts and advanced gene tracking in mouse models. Learn practical breeding schemes to simplify complexity, refine gene expression control, and avoid lethal phenotypes.

Cre-Lox Neurogenetics: 20 Years of Versatile Applications in Brain Research and Counting. Front Genet. 2016;7:19. doi: 10.3389/fgene.2016.00019. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]

Saur B. Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae. Mol Cell Bio . 1987;7(6):2087-2096. Saur B, Henderson N. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1 .

Cre-Lox recombination is a genetic technique that involves the use of the Cre recombinase enzyme to manipulate DNA sequences flanked by specific loxP sites, leading to deletions, inversions, or translocations in a controlled manner.

The Cre-lox system, derived from P1 bacteriophage, is a potent and specific system for controlling gene expression. The protein Cre recombinase recognizes 34 bp loxP sites, and the orientation and location of the loxP sites determines how the genetic material will be rearranged.

What is Cre-lox? The Cre-lox system is a technology that can be used to induce site-specific recombination events. The system consists of two components derived from the P1 bacteriophage: the Cre recombinase and a loxP recognition site.

The Cre-lox recombination method orchestrates remarkable genetic manipulations that remain a gold standard for transgenic mice.

Jan 11, 2025 · Cre-Lox recombination has become an essential tool in genetic engineering, offering precision and flexibility in manipulating genomes. Its ability to facilitate specific DNA modifications has opened new avenues for creating genetically modified organisms (GMOs) …

Mar 2, 2017 · The cre-loxP-mediated recombination system (the "cre-loxP system") is an integral experimental tool for mammalian genetics and cell biology. Use of the system has greatly expanded our ability to precisely interrogate gene function in the mouse, providing both spatial and temporal control of gene exp …