2025年2月27日 · You save time by assessing efficacy with native post-translational modifications and, for membrane proteins and mammalian display, on mammalian cell membranes. TARGATT™ is great for cell therapy development

2024年10月15日 · By using a FluidFM® Nanosyringe, the smallest needle in the world, to inject CRISPR/Cas9 ribonucleoproteic (RNP) complexes directly into the nucleus of single cells, CellEDIT bypasses the need for vectors.

Cre- loxP system is a widely used powerful technology for mammalian gene editing. This system has advantages which is very simple manipulation and do not require additional factors for efficient recombination [1].

2024年5月1日 · Scale up your primary cell-based research by using large-scale peripheral blood sources such as whole blood or leukopaks. These single-donor cell sources increase the physiological relevance of cell culture systems, enabling you to generate meaningful data that is more predictive of in vivo outcomes.

2023年9月26日 · Here, we investigate five of the most widely available microglial inducible Cre lines. We demonstrate varying degrees of recombination efficiency, cell-type specificity, and spontaneous recombination, depending on the Cre line and inter- loxP distance.

Taking advantage of two orthogonal recombinases Cre and Dre, we recently used the combination of the Cre-loxP and Dre-rox systems to lineage trace stem cells in lung and artery wall (35, 46), record cell proliferation in liver and heart (40, 47), trace EMT in cancer metastasis and fibrosis (48, 49), and elucidate the role of cardiac stem cells ...

2015年4月1日 · Analysis of CREX mutants showed drastic downregulation of HEV RNA replication in S10-3 cells. The mutant RNA were efficiently encapsidated but produced poorly infectious virions. The data therefore, suggests strict conservation of the CREX structure, essential for HEV life cycle.

In traditional Asian medicine, dried rhizomes of Ligusticum chuanxiong Hort. (Chuanxiong Rhizoma [CR]) have long been used to treat pain disorders that affect the head and face such as headaches. Furthermore, they have been used primarily for blood circulation improvement or as an analgesic and anti-inflammatory medicine.

2017年3月2日 · The cre-loxP-mediated recombination system (the "cre-loxP system") is an integral experimental tool for mammalian genetics and cell biology. Use of the system has greatly expanded our ability to precisely interrogate gene function in the mouse, providing both spatial and temporal control of gene exp …

2024年6月10日 · Cytosurge’s CellEDIT Service provides high-quality cell lines for research purposes. This innovative service represents a novel workflow leveraging Cytosurge’s proprietary FluidFM® technology to perform intranuclear injection …