
CRKL Gene - GeneCards | CRKL Protein | CRKL Antibody
2024年12月24日 · CRKL (CRK Like Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRKL include Digeorge Syndrome and Hemorrhage, Intracerebral. Among its related pathways are MET promotes cell motility and …
CRKL - Wikipedia
Crk-like protein is a protein that in humans is encoded by the CRKL gene. [5][6] v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion.
Crk and CrkL adaptor proteins: networks for physiological and ...
2009年5月10日 · Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections.
CRKL CRK like proto-oncogene, adaptor protein [ (human)]
Data show that miR-193b, by directly targeting focal adhesion kinase (FAK), CRK-like proto-oncogene (CRKL), and methionine sulfoxide reductase A (MSRA), regulates focal adhesion signaling and ROS signaling, which play pivotal roles in …
CRK 样原癌基因、衔接蛋白(CRKL)基因 | MCE
该基因编码含有 SH2 和 SH3 (Src 同源) 结构域的蛋白激酶,已显示可激活 Ras 和 JUN 激酶信号通路并以 Ras 依赖性方式转化成纤维细胞。 它是 Bcr-Abl 酪氨酸激酶的底物,在 Bcr-Abl 的成纤维细胞转化中发挥作用,并且可能具有致癌性。 [RefSeq 提供,2009 年 1 月]
【合作文章,IF=25.7】CyTOF发现CRKL通过介导肝癌中肿瘤相关 …
近期,复旦大学李辉、郭磊、叶青海、樊嘉及中国台湾中国医科大学洪明奇等合作在 Journal of Hepatology(IF=25.7) 在线发表题为 “ CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatoce” 的研究论文,文中 使用 CyTOF技术 发现受CRKL调控的关键亚群 PD-L1+ TANs,并揭示了CRKL通过介导肝癌中肿瘤相关中性粒细胞浸润来调控抗PD-1耐药性的机制。 CRKL在抗PD-1耐药的HCC中显著上调。 CRKL与 β-连环蛋白 结合,抑 …
CRKL regulates alternative splicing of cancer-related genes in …
2019年5月27日 · CRKL is tightly linked to leukemia via its binding partners BCR-ABL and TEL-ABL, upregulated in multiple types of human cancers, and induce cancer cell proliferation and invasion. However, it remains unclear whether signaling adaptors such as CRKL could regulate alternative splicing.
J Hepatol | 复旦大学李辉/郭磊/叶青海/樊嘉合作等发现CRKL调控 …
2024年2月25日 · CRKL过表达通过动员肿瘤相关中性粒细胞 (TANs)阻断CD8+ T细胞的浸润和功能而使抗PD-1治疗效果无效。 PD-L1+ TANs被发现是TANs的一个重要子集,受CRKL表达调节,并表现出免疫抑制表型。 在机制上,CRKL通过竞争性地降低Axin1结合抑制APC介导的β连环蛋白蛋白酶体降解,从而促进VEGFα和CXCL1的表达。 使用人类HCC样本,验证了CRKL/β-catenin/VEGFα与CXCL1的正相关。 利用CRISPR-Cas9基因编辑 (CRKL敲除)靶向CRKL或其 …
接头蛋白Crk与肿瘤 - 中国生物化学与分子生物学报
Crk是一种重要的细胞内信号接头蛋白,含有SH2和SH3结构域,在信号传递过程中不仅承上启下,对信号强度还有着调控作用.迄今主要发现了4种Crk分子,即v Crk、CrkⅠ、CrkⅡ和CrkL (Crk...
CRKL重组蛋白:研究细胞信号传导的重要工具 - 哔哩哔哩
而Crk样蛋白 (CRKL)作为一种蛋白质信号调控分子,扮演着重要的角色。 本文将介绍CRKL的基本特征,重组蛋白的制备以及其在科学研究中的应用。 艾普蒂生物 目录号:PA1000-713. 一、CRKL的基本特征 CRKL是一种酪氨酸激酶耦联蛋白,它由105个氨基酸组成,分子量约为42kDa。 CRKL的结构包括N端的Src同源结构域以及C端的Src二黏性结构域,这两个结构域分别与信号通路中不同的蛋白质相互作用,从而调控细胞信号传导。 二、CRKL重组蛋白的制备 艾普蒂生 …