Broadly therapeutic antibody provides cross-serotype ... - Nature
2024年10月18日 · Here, using function-based screening, we identify a broadly therapeutic antibody h1A6.2 that potently protects mice in lethal models of infection with both enterovirus …
Serological Cross-Reactions between Expressed VP2 Proteins from ...
The 3D maps shown here indicate a broad range of cross-reactivities within and between BTV serotypes and nucleotypes, clustering the VP2 proteins of all BTV serotypes in one large …
A Broadly Cross-protective Vaccine Presenting the Neighboring
2015年8月5日 · We demonstrate that anti-VP2 (aa141-155) sera bound authentic CA16 viral particles, whereas anti-VP1 (aa208-222) sera could not. Moreover, the anti-VP2 (aa141-155) …
Protection against Lethal Enterovirus 71 Challenge in Mice by a ...
2014年2月18日 · We have provided a detailed characterization of the cross-neutralizing epitope of VP2 between the mature virion and the expanded particle by using the high-resolution …
A cross-reactive mouse monoclonal antibody against rhinovirus …
2020年6月16日 · VP1-specific, cross-reactive antibodies, especially those with ADCP activity, could contribute to protection against RV infections. Rhinoviruses (RVs) belong to the family of …
The VP2 protein exhibits cross-interaction to the VP1 protein in ...
2022年6月1日 · As a helper of stabilizing and coordinating the formation of virus-like particles (VLPs), we asked whether VP2 interacted with the major capsid protein (VP1) in GII.17 and if …
Global distribution, cross-species transmission, and receptor …
2024年6月20日 · CPV-2c variant is crucial for cross-species from Carnivora to Artiodactyla and Lepidoptera of CPV-2. Loop region variants are key factors in CPV-2 cross-species transmission.
VP2 Dominated CD4+ T Cell Responses against Enterovirus 71 and Cross …
2013年8月15日 · We demonstrated that the VP2 Ag with broad distribution of immunogenic peptides dominates T cell responses against EV71 compared with VP1, VP3, and VP4. …
Serological Cross-Reactions between Expressed VP2 Proteins from ...
2021年7月26日 · Rabbit antisera were more cross-reactive in SNT, and showed widespread, high titre cross-reactions against homologous and heterologous rVP2 proteins in ELISA. Results …
Impact of VP2 structure on antigenicity: comparison of BTV1 and …
2024年9月25日 · The neutralizing antibody responses, which target VP2 epitopes, are predominantly serotype specific, although evidence of sporadic, low-level, cross-neutralization …