2016年1月14日 · As PIF4/5 act downstream of CRYs and PHYs to transduce blue- and red-light signals, respectively, these proteins represent a molecular basis for cross talk between these photosensory pathways. This work provides mechanistic detail to our understanding of how CRYs regulate plant growth.

2015年12月22日 · Arabidopsis blue light photoreceptor cryptochrome 1 (CRY1) represses high temperature-induced hypocotyl elongation through PHYTOCHROME-INTERACTING FACTOR 4 (PIF4). CRY1 physically interacts with PIF4 in a blue light-dependent manner to repress the transcription activity of PIF4.

2020年3月26日，农科院 刘斌 研究组在Plant Communications上发表了 “Cryptochrome 1 Inhibits Shoot Branching by Repressing the Self-activated Transcription Loop of PIF4 in Arabidopsis”的研究论文，研究表明蓝光受体隐花素CRY1能够通过抑制PIF4的转录自激活，来调控拟南芥莲座叶分 …

2016年1月5日 · CRY1 represses auxin biosynthesis in response to elevated temperature through PIF4. Our results indicate that CRY1 signal by modulating PIF4 activity, and that multiple plant photoreceptors [CRY1 and PHYTOCHROME B (PHYB)] and ambient temperature can mediate morphological responses through the same signaling component-PIF4.

2024年8月26日 · In addition, while ABI4 could directly activate its own expression, CRYs enhance, whereas PIF4 inhibits, ABI4-mediated activation of the ABI4 promoter. Together, our study demonstrates that the ABI4–PIF4 module plays an important role in mediating CRY-induced B light signaling in Arabidopsis.

2025年2月26日 · 这一新机制在植物发育的精细调控中具有重要意义：通过精确调控pif4，植物能够根据蓝光信号的变化，灵活调整自身的生长发育，从而更好地适应光照强度、光周期和温度波动等外部环境的动态变化。

摘要：植物细胞伸长是植物生长和形态建成的主要方式之一，受到激素和环境信号等许多因素调控，而光敏色素PHY B互作蛋白PIF4可以促进植物在环境温度升高后的形态建成即热形态建成，但PIF4在这个响应过程中全基因组水平调控的下游基因未见报道。 本研究进一步通过遗传实验证明PIF4在热形态建成中发挥着重要的作用。 通过RNA-Seq实验分析得到热形态建成中248个 PIF4 依赖的和21个 PIF4 部分依赖的下游基因，包括生长素信号通路和非生物逆境响应基因。 结合已 …

植物cry发生蓝光依赖的多聚化激活，光激活的cry能够被蛋白激酶ppks磷酸化，并被e3泛素连接酶cul4cop1-spas和cul3lrbs降解。 蓝光受体CRY1可通过与热形态建成关键转录因子 PIF4 及转录因子 TCP17 相互作用调节拟南芥在温和高温（28°C）下的热形态建成，然而，CRY如何 ...

cry1-pif4通过调控温度升高时生长素合成基因yuc8的表达而调控生长素合成及下胚轴伸长。 CRY1通过与PIF4相互作用而直接结合到YUC8等基因的启动子上直接调控基因表达，以实现环境信号对基因表达的快速调控。

2021年12月1日 · PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) was initially identified as a key component of the Arabidopsis thaliana phytochrome signalling pathway. It was then identified as playing a central role in promoting plant hypocotyl growth via the activation of auxin synthesis and signalling-related genes.