2024年12月24日 · CTBP2 (C-Terminal Binding Protein 2) is a Protein Coding gene. Diseases associated with CTBP2 include 46,Xy Sex Reversal 9 and Neurodevelopmental Disorder With Cerebellar Atrophy And Motor Dysfunction. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Autodegradation of the E3 ubiquitin ligase COP1.

C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene. [5][6][7] The CtBPs - CtBP1 and CtBP2 in mammals - are among the best characterized transcriptional corepressors. [8] . They typically turn their target genes off.

2021年7月13日 · CtBP1/2 knockdown induced cancer cell apoptosis, increased genetic instability, and enhanced the sensitivity to DNA damage agents, such as γ-irradiation and chemotherapy drug...

CTBP2 is a transcriptional cofactor for RXR-alpha/RAR-alpha. We propose that CtBP2 is an ovarian cancer oncogene that regulates gene expression program by modulating HDAC activity. these data demonstrate that CHIP regulates the steady-state level of CtBP2 as an E3 ubiquitin ligase and determines the expression levels of CtBP2 target genes.

2021年11月2日 · Here we describe a hepatic system in this context orchestrated by the transcriptional corepressor C-terminal binding protein 2 (CtBP2) that harbors metabolite-sensing capabilities. The repressor...

C-terminal binding proteins (CtBP1/2) are transcriptional coregulators that play a significant role during vertebrate neurodevelopment. This systematic review aims to identify case reports with genetic variants in CTBP1 and CTBP2 associated with ...

2024年3月6日 · CTBP2（C-terminal Binding Protein 2）是一种位于人类染色体10q23.31位置上的基因编码的蛋白质，也称为乙醇敏感的细胞核蛋白（repressor protein of the ethanolsensitive element）。 CTBP2是CTBP家族的成员之一，其功能主要是在细胞内参与转录调控和信号转导过程。 CTBP2是一种含有紧密结合结构域的转录抑制蛋白，具有重要的生物学功能。 CTBP2蛋白的基本信息包括其分子量约为48kDa，由约431个氨基酸组成。 该蛋白在人体中广泛表达，但主 …

Ubiquitous expression in thyroid (RPKM 13.6), endometrium (RPKM 9.4) and 24 other tissues. 该基因产生编码两种不同蛋白质的替代转录物。 一种蛋白质是转录抑制因子，而另一种亚型是称为突触带的特殊突触的主要成分。 两种蛋白质都含有一个 NAD+ 结合结构域，类似于 NAD+ 依赖性 2-羟基酸脱氢酶。 3' 非翻译区的一部分用于将该基因映射到染色体 21q21.3；然而，有人指出，基因组其他地方也可能存在类似的位点。 Blast 分析显示该基因存在于 10 号染色体上。 已发现该 …

CtBP2直接抑制FoxO1介导的肝糖异生，也可间接抑制固醇调控元件结合蛋白1介导的 脂肪生成 。 NADH/NAD和酰基辅酶A之间的代谢不平衡，肝脏特异性CtBP2缺失时，会促进肝糖异生，导致肥胖相关的代谢紊乱，加速 脂肪性肝炎 的进展，相反，CtBP2的激活可改善肥胖患者 ...

2012年11月19日 · When tethered to a promoter by a heterologous DNA-binding domain, Ctbp2 functioned as a potent repressor. Ctbp2 also interacted with the mammalian transcription factors Evi1 (165215), Tcf8, and Fog (ZFPM1; 601950). Turner and Crossley (1998) concluded that CTBP2 is a mammalian corepressor that targets diverse transcriptional regulators.