In humans, cathepsin B is encoded by the CTSB gene. [6][7] Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, and in various other pathological conditions. [8][9][10][11] The CTSB gene is located at chromosome 8p 22, consisting of 13 exons.

2024年12月24日 · CTSB (Cathepsin B) is a Protein Coding gene. Diseases associated with CTSB include Keratolytic Winter Erythema and Hyperparathyroidism, Neonatal Severe. Among its related pathways are Collagen chain trimerization and Innate Immune System.

CTSB is a direct target gene of miR-140, and overexpression of miR-140 reduces CTSB levels, enhances temozolomide cytotoxicity, inhibits mesenchymal transition, and affects CTSB-regulated tumor spheroid formation and expression of stemness markers.

Cathepsin B (CTSB) is a novel target gene of hypoxia-inducible factor-1-alpha (HIF-1alpha). CTSB mRNA and protein levels can be up-regulated in a HIF-1alpha-dependent manner. expression of cathepsin B and X was detected in stromal cells and cancer cells throughout the glioblastoma (GBM) sections, whereas cathepsin K expression was more ...

2025年2月9日 · A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of cathepsin B (CTSB) expression by HIV-1 Vpr in Vpr transduced macrophages

2024年4月5日 · CTSB exhibits activity under acidic conditions (pH 3.0–7.0) and irreversible deactivation under alkaline conditions [3]. The human CTSB protein is encoded by the CTSB gene, which is located on chromosome 8p22 and consists of 13 exons.

Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and aging animal models.

2012年2月8日 · This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products.

This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcr ipt variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products.

A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcr ipt variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products.

2018年8月28日 · Wang et al. (1987) assigned the CTSB gene to chromosome 8p22 by means of a cDNA probe used in Southern blot analysis of somatic cell hybrids and in situ hybridization.

2024年11月25日 · Variants in the CTSB gene encoding the lysosomal hydrolase cathepsin B (catB) are associated with increased risk of Parkinson’s disease (PD). However, neither the specific CTSB variants driving these associations nor the functional pathways that link catB to PD pathogenesis have been characterized.

2008年4月1日 · The gene for human cathepsin B is located on chromosome 8p22 and it comprises 12 exons. The transcript length is 1017 bps which are translated to 339 residues preproenzyme. Cathepsin B mRNA consists of several variants produced by alternative exon splicing. Most variations involve the 5- and 3-UTR.

Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and aging animal models.

The CTSB (cathepsin B) is a protein-coding gene located on chromosome 8. Cathepsin B is a lysosomal cysteine protease involved in intracellular proteolysis. It is encoded by the CTSB gene on chromosome 8p22, containing 13 exons.

2023年11月11日 · Cathepsin B (catB, encoded by the CTSB gene) is a proteolytic enzyme of the cysteine cathepsin family with endo- and exo-peptidase activity that is normally localized to the lysosomal lumen 8. CatB has been implicated both in the lysosomal degradation of α-syn and as a genetic risk factor for PD.

This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products.

The human CTSB gene is located on chromosome 8 and the alleles described here can potentially be used as markers in linkage and association studies of cancers and other diseases . The S2 binding site specificity of this enzyme has been altered to mimic that of cathepsin B or L by the application of site-directed mutagenesis at these latter ...

2025年3月25日 · Ferroptosis is an iron-dependent form of regulated cell death characterized by the accumulation of iron-dependent lipid peroxides, which has been implicated in the pathogenesis of various diseases, and therapeutic agents targeting ferroptosis are emerging as promising tools for cancer treatment. Current research reveals that ferroptosis-targeted …