2024年5月1日 · Our study reveals pronounced ferroptosis in microglia and identifies the target gene, cathepsin B (Ctsb), by analyzing differentially expressed genes following ICH. Ctsb, a cysteine protease primarily located in lysosomes, becomes a focal point in our investigation.

2019年2月13日 · In the embryonic clusters, the lysosome-related genes Ctsb (which encodes cathepsin B), Ctsd (which encodes cathepsin D) and Lamp1 (which encodes lysosomal-associated membrane protein 1) were...

2024年2月1日 · On average, 63.7% of Lyz2 + cells, 91.65% of CD11b + cells, 83.78% of F4/80 + cells, and 43.77% of IBA1 + cells expressed CTSB. However, CTSB was not detected in GFAP-positive regions (Fig. 4F). These results confirmed that macrophages accumulate lipid peroxides after injury, and CTSB is highly expressed in macrophages, which is consistent with ...

2023年8月13日 · MoMFs（IBA1+CLEC4F–：IBA1为巨噬细胞marker，CLEC4F为Kupffer细胞marker）从24h开始出现并逐渐增加，使用GFP+骨髓细胞进行移植实验显示，包裹坏死组织的细胞是骨髓来源的MoMFs（图1B-C）。

2025年2月26日 · Our findings uncover a vital interplay between immune and barrier cells that accelerates CP and brain aging, identify CTSS as a potential target to improve brain homeostasis in aged animals, and underscore the critical role of circulating proteinases in aging.

2024年3月8日 · 我们的研究揭示了小胶质细胞中明显的铁死亡，并通过分析 ICH 后的差异表达基因来鉴定目标基因组织蛋白酶 B (Ctsb)。 Ctsb 是一种主要位于溶酶体中的半胱氨酸蛋白酶，成为我们研究的焦点。

2024年6月22日 · By inhibiting CTSB, miR-223 promotes selective LD degradation, thereby reducing the lipid burden and inflammatory phenotype in LDAM. This study broadens the understanding of the molecular mechanisms of lipophagy and proposes lipophagy induction as a potential therapeutic approach to mitigate inflammatory responses in demyelinating diseases.

2023年8月8日 · Expression of CTSB and ECE1, 2 well-known targets of HIF1α (39, 40) was significantly reduced in IBA1 + MoMFs from myeloid cell–specific Hifa-knockout (Hif1a mye–/–) mice compared with those from WT mice after ConA treatment (Figure 7D).

(A) UMAP plot showing the expression of Ctsb, Cd86, and Mrc1 in macrophages after SCI. (B) The calculated cell proportion of CTSB, CD86, and Mrc1 positive cells in macrophages after SCI. (C) The expression level of Ctsb in Cd86+ Mrc1-macrophages and …

CysC exhibited potential in ameliorating SBI following ICH via effectively suppressing the activation of the NLRP3 inflammasome mediated by CTSB specifically in microglial cells. These findings underscore the prospective therapeutic efficacy of …