心肌细胞特异性LAMP-2B敲除会导致心肌收缩异常，这表明LAMP-2B是导致心肌细胞代谢缺陷的原因。 Rocket Pharmaceuticals正在进行的1期临床试验的研发管线RP-A501， 通过AAV载体 …

2025年3月13日 · We demonstrate that elevated lysosomal cathepsin B (CTSB) levels and CTSB leakage to the cytoplasm triggers amyloidogenesis in two neurological LSDs.

2024年11月13日 · Remarkably, elevated LAMP-1 expression substantially reduced zinc-induced toxicity (Fig. 5E) and prevented zinc-induced LMP and CTSB release into the cytosol in HEK …

2021年3月23日 · Cathepsin B (CTSB) and L (CTSL) are cysteine proteases, and Cathepsin D (CTSD) is an aspartic protease 8. These cathepsins are major lysosomal proteases and are …

2018年9月3日 · Our study demonstrates that a significant portion of LAMP1-labeled organelles do not contain detectable lysosomal hydrolases including cathepsins D and B and …

2022年7月1日 · Particularly, alterations in lysosomal cathepsins CTSD, CTSB and CTSL can contribute to the pathogenesis of neurodegenerative diseases as seen for neuronal ceroid …

2017年6月8日 · Simultaneously, Pb inhibited lysosomal degradation capacity by affecting the maturation of cathepsin B (CTSB) and cathepsin D (CTSD). Furthermore, translocation of …

While WT cells mostly displayed processed (active) CTSB and high levels of glycosylated LAMP1, CTSB was only partially processed and LAMP1 levels were diminished in both cl 2 and cl 3 …

2023年6月25日 · Our findings showed that T3 activates rapid lysosomal turnover and expression of numerous lysosomal genes, including TFEB, LAMP2, ARSB, GBA, PSAP, ATP6V0B, …

2024年12月23日 · 然后获得缺血半暗带的脑组织，分别用Beclin-1、LC3、SQSTM1/P62、Ubiquitin、LAMP-2、Cathepsin B、Cathepsin D抗体通过蛋白质印迹法（Western …