2022年4月24日 · Protein S-nitrosylation is known to regulate enzymatic function. Here, we report that nitric oxide (NO)-related species can contribute to Alzheimer’s disease (AD) by S-nitrosylating the lysosomal...

2017年12月5日 · BAG2 regulates pro-cathepsin B/annexin II complex formation and facilitates the trafficking of pro-cathespin-B-containing TGN38-positive vesicles toward the cell periphery, leading to the secretion of pro-cathepsin B, which induces metastasis.

Proteintech's Rabbit Polyclonal Cathepsin B antibody is validated in WB, IHC, ELISA and shows reactivity with human, mouse samples.

2018年1月19日 · Isolated pro-CTSB from rat microsomal fraction was activated by CTSD in vitro under acidic conditions and was blocked by the aspartic protease inhibitor pepstatin A (38, 39). Our results indicate that this CTSD-mediated activation of CTSB represents the predominant activation mechanism for CTSB, applies equally to nonmalignant cells and in vivo ...

2015年11月24日 · Degradation of the endogenous tissue inhibitors of metalloproteinases (TIMPs) by CTSB increases the pro-angiogenic functions of matrix metalloproteinases (MMPs) within the tumour...

During tumor development and progression, CTSB has two opposing effects. Its pro-apoptotic properties reduce malignancy, while its proteolytic enzymatic activity promotes invasion and metastasis, thereby inducing malignancy. Here, we discuss the roles of CTSB in tumor and non-tumor disease pathophysiologies.

2024年4月5日 · CTSB co-localizes with the cell surface protein annexin A2 to promote invasiveness and angiogenesis by activating the PI3K/Akt pathway. Besides CTSB activates pro-uPA to become uPA, which can digests ECM proteins and activates MMPs to degrade the ECM to promote invasiveness and angiogenesis.

2025年1月23日 · Regular physical activity (PA) is beneficial for cognitive health, and cathepsin B (CTSB) – a protease released by skeletal muscle during PA – acts as a potential molecular mediator of this association. PA-induced metabolic and mechanical stress appears to increase plasma/serum CTSB levels.

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the heavy chain subunit of human cathepsin B protein. Cathepsin B (CSTB), part of the papain family of proteases, is a widely expressed lysosomal cysteine endopeptidase (1,2).

2013年9月30日 · Genetic deficiency or pharmacological inhibition of CTSB attenuates tumor growth, invasion and metastasis in mouse models of human cancers. CTSB is expressed in both cancer cells...