2024年1月15日 · In the diabetic wound model of GK rats, the PAG-CuS hydrogel reduced ROS levels, increased microvessel count, improved epithelialization, and enhanced wound healing. Therefore, this versatile photothermal hydrogel has the potential to be applied in sterilization, scavenging free radicals, and promoting angiogenesis, making it an effective and ...

2024年1月15日 · To address this issue, we developed a multifunctional photothermally responsive hydrogel (PAG-CuS) as an effective platform for managing the entire wound-healing process, including promoting wound healing, providing anti-inflammatory therapy, and performing photothermal sterilization.

PAG-CuS 由丙烯酸 (AA)、甲基丙烯酸酐改性明胶 (GelMA) 和硫辛酸钠 (LAS) 包覆的硫化铜纳米颗粒 (CuS@LAS) 共聚而成，具有多孔三维结构，可促进细胞粘附并具有相当大的持水能力。 此外，内部的CuS@LAS不仅赋予水凝胶光热抗菌性能，而且还充当物理交联剂，从而增强其机械强度。 在近红外诱导的光热效应下，多孔水凝胶释放出CuS@LAS，随后CuS@LAS通过胶束解组装排出LAS，消除细胞内ROS。 这导致 MMP-9 表达下调，促进 ECM 产生并促进伤口愈合。 同 …

2023年12月5日 · 近日，Acta biomaterialia发表的一篇论文提出了一个多功能光热响应水凝胶（PAG-CuS），作为一个有效的平台来管理整个创伤愈合过程，包括促进创伤愈合、提供抗炎疗法和进行光热灭菌。

2022年6月3日 · Herein, CuS nanoparticle-PEG soft hydrogel-coated 3D hard polycaprolactone scaffolds (denoted as CuS-PEG-PCL scaffold) are rationally designed for efficient bone regeneration. CuS nanoparticles cross-linked PEG hydrogel (CuS-PEG-hydrogel) endows the PCL-based scaffold with excellent photothermal properties and stable soft elasticity, while the ...

2022年7月31日 · CuS NPs交联PEG水凝胶，赋予PCL支架优异的光热性能和稳定的软弹性，同时，PCL支架提供优异的机械性能。 在1064 nm近红外光照射后，储存在CuS-PEG-PCL支架中的地塞米松磷酸钠 (Dexp)实现可控释放，有效促进骨间充质干细胞 (BMSCs)的成骨分化。 此外，42 ± 0.5°C温和热进一步促进BMSCs的成骨分化。...

硫化铜（CuS）纳米粒子是一种重要的过渡金属硫化物，作为一种p型半导体，其性质稳定，对近红外光有强烈的吸收，因而常被作为光电材料。 很多人不知道的是，CuS作为光热剂在生物医学领域也得到了广泛关注，可以用于…

2022年6月3日 · CuS nanoparticles cross‐linked PEG hydrogel (CuS‐PEG‐hydrogel) endows the PCL‐based scaffold with excellent photothermal properties and stable soft elasticity, while the PCL scaffold provides...

2020年1月1日 · CuS NPs were synthesized by a simple CCP method by changing the copper precursors and Cu/S molar ratio for fixed sulphur source (thiourea) using green solvent such as deionised water.

2019年9月17日 · Based on the difference spectra of cell membranes and the associated water, we clearly revealed that Cu 2+ ions produced by the degradation of PEG-CuS can coordinate with PEG, thus changing the interaction between nanoparticles and cells including how and how many nanoparticles enter the cells and the sequential photothermal effect, which ...