Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information.

2016年9月23日 · Here we report the solution structure of the Cuz1 AN1 ZnF which reveals a compact C6H2 zinc-coordinating domain that resembles a two-finger hand holding a tri-helical clamp. A central phenylalanine residue sits between the two zinc-coordinating centers.

2014年1月1日 · Cuz1/Ynl155w functions as a zinc-dependent ubiquitin-binding protein. Thus, Cuz1/Ynl155w is proposed to protect cells from metalloid-induced proteotoxicity by delivering ubiquitinated substrates to Cdc48 and the proteasome for destruction.

Here we report the solution structure of the Cuz1 AN1 ZnF which reveals a compact C6H2 zinc-coordinating domain that resembles a two-finger hand holding a tri-helical clamp. A central phenylala-nine residue sits between the two zinc-coordinating centers.

2016年3月1日 · Cuz1 is one of two AN1 ZnF proteins in the yeast S. cerevisiae, and is a stress-inducible protein that functions in protein degradation through direct interaction with the proteasome and Cdc48. Here we report the solution structure of the Cuz1 AN1 ZnF which reveals a compact C6H2 zinc-coordinating domain that resembles a two-finger hand holding ...

Here we characterize the Cuz1 protein (C dc48-associated U BL/ z inc finger protein-1), encoded by a previously uncharacterized arsenite-inducible gene in budding yeast. Cuz1, like its human ortholog ZFAND1, has both an AN1-type zinc finger (Zf_AN1) and a divergent ubiquitin-like domain (UBL). We show that Cuz1 modulates Cdc48 function in the UPS.

Enables proteasome binding activity. Involved in cellular response to arsenic-containing substance and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Orthologous to several human genes including ZFAND1 (zinc finger AN1-type containing 1). [provided by Alliance of Genome Resources, Feb 2025]

2018年6月7日 · ZFAND1 is the hitherto uncharacterized human homolog of Cuz1, a protein implicated in the arsenite response of yeast cells (Hanna et al., 2014; Sá-Moura et al., 2013).

2016年9月23日 · Here we report the solution structure of the Cuz1 AN1 ZnF which reveals a compact C6H2 zinc-coordinating domain that resembles a two-finger hand holding a tri-helical clamp. A central phenylalanine residue sits between the two zinc-coordinating centers.

CUZ1 / YNL155W Sequence Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.