C. elegans Wnt homolog, cwn-1, functions to regulate asymmetric division of the ABpl/rpppa blast cell. Cwn-1 does not act alone in this process, and it functions with another redundant ligand …

2009年4月15日 · In the ABpl/rpppa neuroblast division, however, we determined that DSH-2 regulates cell polarity through a β-catenin independent Wnt pathway. We also established that …

2024年11月1日 · So et al. also identified three specific Wnt ligands – CWN-1, CWN-2 and EGL-20 – that collectively control the polarity of Z1 and Z4. Each protein has a distinct role: CWN-1 …

three Wnt proteins (CWN-1, CWN-2, and EGL-20) with distinct functions. In lin-17 mutants, CWN- 2 promotes normal polarity in both Z1 and Z4, while CWN-1 promotes reverse and normal …

2024年11月1日 · Each protein has a distinct role: CWN-1 promotes Z1 and Z4 to have the same polarity, while CWN-2 induces the polarity of Z1 cells to reverse. EGL-20 then stops Z1 from …

2016年12月13日 · Mutation of cwn-1 or lin-44 gene induced a resistant property to GO toxicity and resulted in the decreased accumulation of GO in the body of nematodes, whereas …

2024年4月24日 · Functional genetic analysis revealed that CWN-1 is required downstream of MAB-5 to inhibit anterior migration of the QL lineage, likely in parallel to EGL-20/Wnt in a …

2023年11月9日 · Genes affected by mab-5 included those involved in neurogenesis, neural development, and interaction with the extracellular matrix. cwn-1, which encodes a Wnt …

2024年7月19日 · In this study, we show that SEL-5, the C. elegans orthologue of mammalian AP2-associated kinase AAK1, acts together with the retromer complex as a positive regulator …

We show that three of the Wnts, CWN-1, CWN-2, and EGL-20, play major roles in directing cell migrations and that all five Wnts direct specific cell migrations either by acting redundantly or …