2018年5月5日 · USP8 reduces both multiple monoubiquitination and polyubiquitination of Cx43 to prevent autophagy-mediated degradation. Consistently, knockdown of USP8 results in …

2023年10月30日 · After treatment with TSZ for 10 h, S454A mutant of MLKL increased the K48-linked ubiquitination of Cx43 (Fig. 3C, lane 5, K48-Ub) in contrast to MLKL (WT) (lane 4), but …

2011年7月15日 · The tyrosine-sorting signal (YXXØ), present at amino acids 286-289 of Cx43 (connexin43), has been implicated in the internalization of the protein. In recent years, …

2011年6月28日 · Immunofluorescence, cycloheximide-chase and cell-surface-protein biotinylation experiments demonstrate that oligomerization of Cx43–Ub into hemichannels containing wild …

2015年5月1日 · By confocal microscopy, we show that ischemia induces extensive co-localization of ubiquitin and Nedd4 with Cx43 localized at IDs. Moreover, by subcellular fractionation and …

2012年6月1日 · As shown in Figure 6H, interaction between p62 and Cx43 significantly increased in cells expressing Cx43-Ub. Taken together, these data suggest that Nedd4-mediated …

In this study, we demonstrate that Cx43 is modified with lysine 63-linked polyubiquitin chains and that these increase the interaction between Cx43 and AMSH. We also show that AMSH is …

2018年5月1日 · USP8 reduces both multiple monoubiquitination and polyubiquitination of Cx43 to prevent autophagy-mediated degradation. Consistently, knockdown of USP8 results in …

2020年3月5日 · In the present work, we demonstrate that knockdown of EHD1 impaired the internalization of Cx43, preserving gap junction-intercellular coupling in cardiomyocytes. …

Here, we report that the ubiquitin-specific peptidase 8 (USP8) interacts with and deubiquitinates Cx43. USP8 reduces both multiple monoubiquitination and polyubiquitination of Cx43 to …