2018年1月2日 · Through a series of crystal structures of CXXC domains with DNA ligands, we unravel the molecular mechanisms of how these CXXC domains, including single CXXC domains and tandem CXXC-PHD domains, recognize distinct DNA ligands, which further supports our classification of human CXXC domains and also provides insights into selective recruitment of...

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene. [5][6][7] Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression. [6]

2018年1月2日 · Here we systematically measured and compared the DNA-binding selectivities of all known human CXXC domains by different binding assays, and complemented the existing function-based classification of human CXXC domains with a …

2021年8月2日 · CXXC5 is a member of the zinc-finger CXXC family that binds to unmethylated CpG dinucleotides. CXXC5 modulates gene expressions resulting in diverse cellular events mediated by distinct signaling...

2016年5月23日 · CXXC finger protein 1 (Cxxc1) is defined as an unmethylated CpG-binding protein regulating DNA methylation through its DNA-binding domain. It is also a component of the H3K4...

2020年3月17日 · The most significant feature of meiosis is the recombination process during prophase I. CXXC finger protein 1 (CXXC1) binds to CpG islands and mediates the deposition of H3K4me3 by the SETD1 complex. CXXC1 is also predicted to recruit H3K4me3-marked regions to the chromosome axis for the generation …

Recently, a family of proteins which encode a ZF-CxxC (zinc finger-CxxC) domain have been shown to specifically recognize non-methylated DNA and recruit chromatin-modifying activities to CGI elements.

CXXC5基因是视色素反应基因,编码视色素诱导的核因子,又可称为RINF。 CXXC5除了作为表观遗传调控因子外,还可以通过调控Wnt/β-catenin 通路参与细胞的生长和分化过程;CXXC5 多种恶性肿瘤的发生发展相关,可以作为TGF-β的靶基因,可活化激活TNF-α ,参与调控肿瘤细胞的生长代谢过程,CXXC5表达情况对肿瘤治疗的预后也有参考作用;CXXC5 对氧反应元件起抑制作用,参与细胞能量代谢等生物学过程。 本文对近年来CXXC5的研究进展作一综述。 *通讯作者。 文章引用: 闵继 …

2020年3月13日 · In this review, we summarize these human CXXC domain-containing proteins in terms of their structures, biology, and biochemistry, and also discuss how they mediate cross-talk among different epigenetic modifications. 80% of CpG dinucleotides in mammalian genomes are found to exhibit methylation.

CXXC5 is a member of the CXXC-type zinc-finger protein family. Proteins in this family play a pivotal role in epigenetic regulation by binding to unmethylated CpG islands in gene promoters through their characteristic CXXC domain.