2024年12月24日 · CYBA (Cytochrome B-245 Alpha Chain) is a Protein Coding gene. Diseases associated with CYBA include Granulomatous Disease, Chronic, Autosomal Recessive, 4 and Chronic Granulomatous Disease.Among its related pathways are Signaling by Rho GTPases and Innate Immune System.Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and SH3 domain binding.

Cytochrome b-245 light chain is a protein that in humans is encoded by the CYBA gene involved in superoxide production and phagocytosis. [5]Cytochrome b-245 is composed of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit, which has been proposed as a primary component of the microbicidal oxidase system of phagocytes.

The CYBA gene provides instructions for making a protein called the cytochrome b-245 alpha chain (also known as p22-phox). This protein is one part (subunit) of a group of proteins that forms an enzyme complex called NADPH oxidase, which plays an …

2025年1月4日 · A functional polymorphism in the NAD(P)H oxidase subunit CYBA is related to gene expression, enzyme activity, and outcome in non-Hodgkin lymphoma. Hoffmann M, et al. Cancer Res, 2010 Mar 15. PMID 20215507; Association of p22phox gene C242T polymorphism with coronary artery disease: a meta-analysis. Fang S, …

CYBA gene polymorphisms modulate the risk of coronary artery disease but do not form a haplotype blocks; The present study is the first to have demonstrated an association between CYBA (rs7195830) polymorphism and the risk of developing coal workers' pneumoconiosis (CWP) in subjects belong to the Han ethnic group in China and provides further ...

cyba的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为细胞色素b由轻链（阿尔法）和重链（测试版）。该基因编码已被提议作为吞噬细胞的杀微生物氧化酶系统的主分量的光，α亚基。在这种基因突变与常染色体隐性慢性肉芽肿病（cgd），其特征是激活的吞噬细 …

CYBA gene (OMIM number 233690) located on the long arm of chromosome 16 at position 24 (16q24: 88,643,288 to 88,651,084, OMIM 608508) contains 6 exons and spans 8.5 kb.. 3 P22 phox structure and physiological role. P22 phox is a transmembrane protein that contains 195 amino acids and has a molecular mass of 22.0 kDa. It associates with NOX2 and with NOX1, NOX3 and NOX4 in a 1:1 complex and has ...

Gene: CYBA ENSG00000051523. Description. cytochrome b-245, alpha polypeptide [Source:HGNC Symbol;Acc:2577] Gene Synonyms. p22-PHOX. Location. Chromosome 16: 88,709,691-88,717,560 reverse strand. ... A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in ...

细胞色素 b-245 α 链： 细胞色素 b 由轻链 (α) 和重链 (β) 组成。该基因编码已被提议作为吞噬细胞杀微生物氧化酶系统的主要成分的轻α亚基。该基因的突变与常染色体隐性慢性肉芽肿病 (CGD) 相关，其特征是活化的吞噬细胞无法产生超氧化物，而超氧化物对于这些细胞的杀微生物活性很重要。

2019年2月19日 · The CYBA gene encodes the alpha subunit, also known as the light chain, of cytochrome b(-245), which is a component of the NADPH oxidase (NOX) complex responsible for the respiratory burst in phagocytes. The CYBB gene is an X-linked gene which encodes the cytochrome b beta subunit, also known as the heavy chain.