Cyclin D1 is mostly known for the role played in the nucleus, as regulator of cell cycle progression. Cyclin D1 modulates the transition from G1 to S phase through its action as allosteric regulator of the cyclin-dependent kinase 4 (CDK) and CDK6.

2024年12月24日 · Complete information for CCND1 gene (Protein Coding), Cyclin D1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

The critical role of cyclin D1-CDK4 in regulating cell cycle progression and the hyperactivation of cyclin D1-CDK4 in human tumors makes this complex an attractive target for cancer treatment. Cyclin D1 does not possess enzymatic activity, making it a challenging therapeutic target.

Cyclin D1，即G1/S-特异性周期蛋白-D1，是一个由人类CCND1基因所编码的蛋白质。Cyclin D1的基因属于高度保守的细胞周期家族。该家族在整个细胞周期中蛋白丰度具有周期性变化。Cyclin D1的作用在于作为细胞周期蛋白依赖性激酶CDKs的调控者。

This review discusses cyclin D1 transcriptional, translational, and post-translational regulations and its biological function with a particular focus on the mechanisms that result in its dysregulation in human cancers.

Cyclin D1 binds to the Cdk4 and Cdk6 to form a pRB kinase. Upon phosphorylation, pRB loses its repressive activity for the E2F transcription factor, which then activates transcription of several genes required for the transition from the G1‐ to ...

2020年11月1日 · Cyclin D1, an important regulator of cell cycle, carries out a central role in the pathogenesis of cancer determining uncontrolled cellular proliferation. In normal cells, Cyclin D1 expression levels are strictly regulated, conversely, in cancer, its …

Cyclin D1 functions in regulation of progression of the cell cycle through the G1 to S phase and in cellular metabolism (Fu, Wang, Li, Sakamaki, & Pestell, 2004). Cyclin D1 plays an essential role in mammary gland development, where it is required for normal lobuloalveolar development.

2023年4月6日 · Cyclin D1 (CCND1), a crucial mediator of cell cycle progression, is the major cyclin involved in transition of cells from the G1 to S phase and plays a vital role in the pathogenesis of cancer...

Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers …