Cyclin E is a member of the cyclin family. Cyclin E binds to G 1 phase Cdk2, which is required for the transition from G 1 to S phase of the cell cycle that determines initiation of DNA duplication.

Cyclin E overexpression not only accelerates the proliferation and division of tumor cells by promoting cell cycle transformation but also induces the expression of related products, leading to chemotherapy resistance.

2021年11月24日 · Cyclin E/CDK2 complex mostly controls cell cycle progression and DNA replication through phosphorylation of specific substrates. Oncogenic activation of Cyclin E/CDK2 complex impairs normal DNA replication, causing replication stress and DNA damage.

Recent reports demonstrate that inappropriate cyclin E expression may have far-reaching biological consequences for cell physiology, including altering gene expression programs governing proliferation, differentiation, survival and senescence.

Cyclin E binds and activates the kinase Cdk2 and by phosphorylating its substrates, the so-called "pocket proteins", the cyclic/Cdk2 complexes initiate a cascade of events that leads to the expression of S-phase specific genes.

2021年5月27日 · E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent kinase 2 (CDK2) and drive cell cycle progression by …

E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent kinase 2 (CDK2) and drive cell cycle progression by phosphorylating several cellular proteins.

Cyclin E is a protein that plays a crucial role in cell-cycle regulation by facilitating centrosome replication and allowing premature entry of cells into the S phase. It is often associated with cell-cycle deregulation in tumors due to its overexpression, leading to potential impacts on chromosome stability.

2005年4月18日 · In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells. Cyclin-dependent kinases control cell cycle transitions. These enzymes contain two...

2004年8月1日 · Cyclin E binds and activates the kinase Cdk2 and by phosphorylating its substrates, the so-called “pocket proteins”, the cyclic/Cdk2 complexes initiate a cascade of events that leads to the expression of S-phase specific genes.