CYP46A1 - 维基百科，自由的百科全书
细胞色素 P450 46A1 （英語： Cytochrome P450 46A1，缩写 CYP46A1）也被称为 胆固醇24-羟化酶 （chilsterol 24-hydroxylase， EC 1.14.13.98），是 细胞色素P450 超家族的一员，由 …
Cholesterol 24-hydroxylase - Wikipedia
Cholesterol 24-hydroxylase (EC 1.14.13.98), also commonly known as cholesterol 24S-hydroxylase, cholesterol 24-monooxygenase, CYP46, or CYP46A1, is an enzyme that …
CYP46A1 Gene - GeneCards | CP46A Protein | CP46A Antibody
2024年12月24日 · CYP46A1 (Cytochrome P450 Family 46 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP46A1 include Pulmonary Disease, Chronic …
中科大刘强教授团队综述：大脑胆固醇代谢及其对学习和记忆的影响
2022年3月20日 · 脑胆固醇转换主要发生在神经元，胆固醇通过 cyp46a1 转化为 24-羟基胆固醇 (24-ohc)。 分泌的 24-OHC 被星形胶质细胞吸收，激活肝 X 受体 (LXR) 并促进 ABCA1 和 …
PloS Biol：武汉大学张振涛课题组揭示胆固醇代谢产物24-OHC与帕 …
研究结果表明，胆固醇24-羟化酶cyp46a1在帕金森病中的α-突触核蛋白病理进展中起着关键作用，突显了其作为帕金森病治疗靶点的潜力。 资讯 生物在线
The potential of CYP46A1 as a novel therapeutic target for …
2023年6月15日 · CYP46A1 converts cholesterol to 24S-hydroxycholesterol (24HC) that readily crosses the blood-brain barrier and reaches the liver for the final elimination process. Studies …
Cholesterol 24-Hydroxylation by CYP46A1: Benefits of ... - PubMed
Cholesterol 24-hydroxylation is the major mechanism for cholesterol removal from the brain and the reaction catalyzed by cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme. This …
CYP46A1 cytochrome P450 family 46 subfamily A member 1
2025年2月8日 · Data suggest that CYP46A1, the enzyme responsible for the majority of cholesterol elimination from the brain, exhibits activation by neurotransmitters, L-glutamate, L …
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein …
2025年2月18日 · Herein, we show that the levels of CYP46A1 and 24-OHC are elevated in PD patients and increase with age in a mouse model. Overexpression of CYP46A1 intensifies α …
细胞色素 P450 家族 46 亚家族 A 成员 1（CYP46A1）基因 | MCE
细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。 这种内质网蛋白在大脑中表达，可将胆固醇转化为 24S-羟基胆固醇。 虽然胆固醇不能通 …