细胞色素 P450 46A1 （英語： Cytochrome P450 46A1，缩写 CYP46A1）也被称为 胆固醇24-羟化酶 （chilsterol 24-hydroxylase， EC 1.14.13.98），是 细胞色素P450 超家族的一员，由 CYP46A1 基因编码，是催化 胆固醇 生成 羟基化 生成 脑甾醇 （24S-羟基胆固醇）的酶 [5]。 Structure of cholesterol-24 hydroxlase (CYP46A1) in Homo sapiens. Based on PyMOL rendering of PDB 2Q9F. ^ Human PubMed Reference:.

Cholesterol 24-hydroxylase (EC 1.14.13.98), also commonly known as cholesterol 24S-hydroxylase, cholesterol 24-monooxygenase, CYP46, or CYP46A1, is an enzyme that catalyzes the conversion of cholesterol to 24S-hydroxycholesterol. It is responsible for the majority of cholesterol turnover in the human central nervous system. [1]

2024年12月24日 · CYP46A1 (Cytochrome P450 Family 46 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP46A1 include Pulmonary Disease, Chronic Obstructive and Alzheimer's Disease. Among its related pathways are Oxidation by cytochrome P450 and Bile acid and bile salt metabolism.

2022年3月20日 · 脑胆固醇转换主要发生在神经元，胆固醇通过 cyp46a1 转化为 24-羟基胆固醇 (24-ohc)。 分泌的 24-OHC 被星形胶质细胞吸收，激活肝 X 受体 (LXR) 并促进 ABCA1 和 ApoE 的转录。

研究结果表明，胆固醇24-羟化酶cyp46a1在帕金森病中的α-突触核蛋白病理进展中起着关键作用，突显了其作为帕金森病治疗靶点的潜力。 资讯 生物在线

2023年6月15日 · CYP46A1 converts cholesterol to 24S-hydroxycholesterol (24HC) that readily crosses the blood-brain barrier and reaches the liver for the final elimination process. Studies show that cholesterol and 24HC levels change during neurological diseases and conditions.

Cholesterol 24-hydroxylation is the major mechanism for cholesterol removal from the brain and the reaction catalyzed by cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme. This review describes CYP46A1 in the context of cholesterol homeostasis in the brain and summarizes available experimental d …

2025年2月8日 · Data suggest that CYP46A1, the enzyme responsible for the majority of cholesterol elimination from the brain, exhibits activation by neurotransmitters, L-glutamate, L-aspartate, gamma-aminobutyric acid, and acetylcholine; L-glutamate-induced CYP46A1 activation may be of physiological relevance.

2025年2月18日 · Herein, we show that the levels of CYP46A1 and 24-OHC are elevated in PD patients and increase with age in a mouse model. Overexpression of CYP46A1 intensifies α-Syn pathology, whereas genetic removal of CYP46A1 attenuates α-Syn neurotoxicity and nigrostriatal dopaminergic degeneration in the brain.

细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。 这种内质网蛋白在大脑中表达，可将胆固醇转化为 24S-羟基胆固醇。 虽然胆固醇不能通过血脑屏障，但 24S-羟基胆固醇可以在大脑中分泌到循环中，回到肝脏进行分解代谢。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the Cytochrome P450 superfamily of Enzymes.