cyp8b1是ca合成关键酶，它决定了非12-oh bas（cdca，α/β-mca，udca，lca, hca, hdca及其他替代途径的衍生物）与12-oh bas（ca，dca）的比例。 最近研究表明，cyp8b1耗竭或下调引起12-oh ba水平减少，从而增加了非-12-oh / 12-oh ba的比例，对宿主代谢状态产生有益影响。

CYP8B1 is an endoplasmic reticulum membrane protein and catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of the two primary bile acids, cholic acid and chenodeoxycholic acid, both of which are secreted in the bile.

2024年12月24日 · CYP8B1 (Cytochrome P450 Family 8 Subfamily B Member 1) is a Protein Coding gene. Diseases associated with CYP8B1 include Intrahepatic Cholestasis Of Pregnancy and Extrahepatic Cholestasis. Among its related pathways are Oxidation by cytochrome P450 and Bile acid and bile salt metabolism.

2025年2月19日 · RORalpha is a key regulator of diurnal rhythm and fasting induction of CYP8B1, which regulates bile acid composition and serum and liver cholesterol levels. Title: Retinoic acid-related orphan receptor α regulates diurnal rhythm and fasting induction of sterol 12α-hydroxylase in bile acid synthesis.

2022年9月1日 · Cytochrome P450 8B1 (CYP8B1), which synthesizes CA, was induced in livers of colitic mice. CA-treated or liver Cyp8b1-overexpressing mice developed more severe colitis with compromised repair of the mucosal barrier, whereas Cyp8b1-knockout mice were resistant to …

甾醇12α-羟化酶（cyp8b1）是一种必需酶，用于合成胆酸和调节肝胆酸的合成以及肠内胆固醇的吸收。本研究评估了固醇调节元件结合蛋白（srebps）在cyp8b1基因调节中的作用。与胆固醇7α-羟化酶（cyp7a1）的上调相反，小鼠和大鼠的胆固醇喂养降低了cyp8b1的活性。

Here, we demonstrated that the hepatic CYP8B1-CA pathway dampened Lgr5 + ISC regeneration by repression of peroxisome proliferator-activated receptor alpha (PPARα)-dependent fatty acid oxidation (FAO), and ultimately promoted colitis, thus uncovering the functional importance of the BA-based liver-gut axis during colitis pathogenesis.

2022年9月6日 · 研究通过肠特异性敲除Pparα的结肠炎小鼠证实了CYP8B1-CA代谢轴通过抑制PPARα介导的FAO，削弱Lgr5 + ISC的更新能力，加重肠道屏障损伤。 研究应用FXR激动剂奥贝胆酸（OCA）间接抑制结肠炎小鼠体内CYP8B1的活性，可促进其Lgr5 + ISC的增殖和传代能力，验证了肝脏FXR-CYP8B1 ...

Human cytochrome P450 8B1 (CYP8B1) is involved in conversion of cholesterol to bile acids. It hydroxylates the steroid ring at C12 to ultimately produce the bile acid cholic acid. Studies implicated this enzyme as a good drug target for nonalcoholic fatty liver disease and type 2 diabetes, but there …

Sterol 12alpha-hydroxylase (CYP8B1) catalyzes cholic acid synthesis in the liver and is feedback inhibited by bile acids. In addition to activating farnesoid X receptor (nuclear receptor subfamily 1H4), bile acids also induce inflammatory cytokines in hepatocytes.