2004年12月24日 · The founding member of the family, human D52, has principally attracted research interest due to its frequent overexpression in cancer, often in association with D52 gene amplification. This review summarises published literature concerning this protein family since their discovery, which is highlighting an increasing diversity of functions for ...

Given the effects of D52 phosphorylation on endosomal and lysosomal membrane trafficking, the present study examined a potential role for D52 phosphorylation in regulating cell division. Results revealed that a phospho-null mutation at serine 136 strongly inhibits cytokinesis.

2021年7月3日 · Tumor protein D52 (TPD52) reportedly plays an important role in the proliferation and metastasis of various cancer cells, including oral squamous cell carcinoma (OSCC) cells, and is expressed strongly at the center of the tumor, where the microenvironment is hypoxic.

2009年12月23日 · Chew et al. recently reported that D52 phosphorylation occurs at S136 and provide additional evidence that it is likely to be mediated by a unique delta6 isoform of CaM kinase II, suggesting that this enzyme may play an important role in regulating D52 secretory function in exocrine epithelia.

TPD52, initially identified to be overexpressed in many human cancers, was found to form a stable complex with AMPK in cancer cells. TPD52 directly interacts with AMPKα and inhibits AMPKα kinase activity in vitro and in vivo. In TPD52 transgenic mice, overexpression of TPD52 leads to AMPK inhibition and multiple metabolic defects.

2024年1月1日 · In prostate cancer (PCa) patients, a proto-oncogene Tumor protein D52 (TPD52) is overexpressed, and it is involved in different cellular functions. In this study, we report that TPD52 expression is positively associated with the emergence of neuroendocrine PCa (NEPC).

TPD52高表达（P <0.05）是影响胰腺癌术后DFS及OS的独立因素。 结论 TPD52有助于胰腺癌患者预后评估,TPD52高表达者预后较差。 关键词: 肿瘤蛋白D52（TPD52）, 胰腺癌, 病理特征, 预后. Abstract: Objective To investigate the expression of tumor protein D52 (TPD52) in...

4 天之前 · Their findings suggest that this regulatory mechanism inhibits tumor growth and proliferation in HCC (Tian et al. 2021). Tumor protein D52 is a family of proteins encoded by the D52 gene family. Research has elucidated the involvement of Tumor Protein D52 (TPD52) ...

2004年12月24日 · Tumor protein D52-like proteins are small coiled-coil motif bearing proteins which are conserved from lower organisms to human. The founding member of the family, human D52, has principally attracted research interest due to its frequent overexpression in cancer, often in association with D52 gene amplification. This review summarises published ...

2004年6月1日 · Based on a meta-analysis of gene expression microarray data from multiple prostate cancer studies (D. R. Rhodes et al., Cancer Res 2002;62:4427-33), a candidate oncogene, Tumor Protein D52 (TPD52), was identified in the 8q21 amplicon. TPD52 is a coiled-coil motif-bearing protein, potentially involved in vesicle trafficking.