2015年12月21日 · We demonstrate that site-specific incorporation of pAMF facilitates near complete conjugation of a DBCO-PEG-monomethyl auristatin (DBCO-PEG-MMAF) drug to the …

Here we describe C lick- A ssisted N CL (CAN), in which peptides are incorporated with traceless “helping hand” lysine linkers that enable addition of dibenzocyclooctyne (DBCO) and azide …

2020年1月29日 · In this study, we combined a non-site-directed antibody conjugation technique using copper-free click chemistry with ion-exchange chromatography to obtain purified single …

2022年11月1日 · We describe practical methods to prepare DOTAGA-DBCO and DFO-DBCO from commercially available starting materials. DOTAGA-DBCO is available in five steps from …

We report a site-selective cysteine-cyclooctyne conjugation reaction between a seven-residue peptide tag (DBCO-tag, Leu-Cys-Tyr-Pro-Trp-Val-Tyr), at the N or C-terminus of a peptide or …

The synthesis of 4- [11,12-didehydrodibenzo [b, f]azocin-5 (6 H)-yl]-4-oxobutanoic acid, also known as dibenzoazacyclooctyne (DBCO) or aza-dibenzocyclooctyne (ADIBO), was optimized …

Successful DBCO-modification was determined by LC-MS (Figure 4(B1,B2) and showed nearly complete conversion by a quantitative shift in the HPLC trace compared to the unmodified …

2023年2月23日 · DBCO (二苯并环辛炔, Dibenzocyclooctyne) 试剂是用于应变促进的炔叠氮化物环加成（SPAAC）的最具反应性的环炔之一，可实现无铜点击化学。 通常利用多肽中的氨基， …

DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain …

DBCO-amine 是一种可降解 (cleavable) 的 ADC linker，用于抗体偶联活性分子 (ADCs) 的合成。 DBCO-amine 是一种点击化学试剂。 它含有 DBCO 基团，可以和含有 Azide 基团的分子发生 …