2024年1月24日 · We report that CCR7 + DCs are the dominant DC population that migrate to the dLN, but a subset remains tumour-resident despite CCR7 expression. These tumour-retained …

2021年7月23日 · CCR7 ligation in DCs induces complicated intracellular signaling pathways involving PI3K/AKT, MAPK/NF-κB, HIF-1α, and IRFs, which feedback to regulate the …

成熟和半成熟DC的 CC趋化因子受体7 （CCR7）表达升高，并向表达CCR7配体CC趋化因子配体21（CCL21）的末端淋巴管迁移。 CCR7与CCL21的相互作用使DC进入淋巴管系统，并最终 …

2024年2月2日 · 2022年11月， Novartis 团队首次在《Blood》杂志公布了JBH-492 的相关研究数据，表明其有可能成为治疗 CCR7 表达淋巴恶性肿瘤的一种前景广阔的ADC候选药物。针 …

CCR7 is expressed by B cells, mature dendritic cells (DCs) and by several T-cell sub-populations including naive, regulatory and central memory T cells. In non-lymphoid organs CCR7 ligands …

In this review, we take an in-depth look at the structural–functional domains of CCR7 and CCR7-bearing dendritic cell trajectory to lymph nodes. Then, we summarize the regulatory network of …

2021年8月3日 · In this review, we discuss the role of dendritic cells (DCs) and the central chemokine receptor CCR7 in the initiation and sustainment of selected chronic inflammatory …

2023年9月1日 · Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and ligand as part of the canonical GPCR desensitization response. …

cc趋化因子受体7（ccr7）在成熟的树突状细胞（dc）上选择性表达。ccr7配体，cc趋化因子配体（ccl）19和ccl21促进成熟dc从周围组织迁移到区域淋巴结。我们以前证明了ccr7配体在成 …

Furthermore, CCR7 is the primary chemokine receptor that drives DC migration to the LN and, in turn, activates pathogenic T cells. Thus, antagonizing CCR7 at the ocular surface has been …