DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds with high affinity to high-mannose type N-glycans, a class of PAMPs (pathogen associated molecular patterns) commonly found

DC-SIGN全称是树突状细胞特异性细胞间粘附分子-3-结合非整合素分子(dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintergrin,DC-SIGN),又称CD209,表达在未成熟的树突状细胞(immature dendritic cells,iDCs)表面,主要作用是捕获抗原和参与细胞间粘附.多种病原体通 …

DC-SIGN is a prototype C-type lectin organized in microdomains, which have their role as pathogen recognition receptors in sensing microbes. Although the integrin LFA-1 is a counter-receptor for both ICAM-2 and ICAM-3 on DC, DC-SIGN is …

2003年9月1日 · Cell- and tissue-specific glycosylation of a glycoprotein regulates the expression of carbohydrate residues and recognition by specific C-type lectins. The C-type lectin DC-SIGN recognizes a wide...

2000年3月3日 · A new DC-restricted molecule, DC-SIGN, demystifies two of this cell's contrasting functions: stimulating T lymphocytes to develop immunity, and enhancing HIV-1 and SIV replication. For immunity, it is implied that DC-SIGN allows …

DC-SIGN, which is expressed by dendritic cells, binds to ICAM-3 on T-lymphocytes, therefore playing an important role in the activation of T-lymphocytes. DC-SIGN can also bind HIV, and the virus may remain bound to DC-SIGN for protracted periods. DC-SIGN may deliver bound HIV to permissive cell types, mediating infection with high efficiency.

Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a type II transmembrane lectin receptor. Attention on DC-SIGN has increased greatly in recent years due to important discoveries documenting its immune-related functions and cell-specific expression that is mostly restricted to DCs.

DC-SIGN is a prototype type II transmembrane protein consisting of a carboxy- (COOH-) terminal carbohydrate recognition domain (CRD), followed by a neck domain consisting of one incomplete and seven complete tandem repeats (numbered 1–7.5) fused to a transmembrane domain (TMD) and ending with an amino- (NH 3 +-) terminal cytoplasmic tail. The ...

dc-sign作为dc表面上的一种受体，在体内发挥着重要作用。 DC-SIGN可以与主要表达于血管和淋巴管内皮细胞上的细胞间黏附分子-2（intercellular adhesion molecule-2，ICAM-2）相互作用，在趋化因子（如：IL-8，MIP-1）的刺激下，使DCs从血液迁移到外周或淋巴结并触发免疫应答 ...

2000年3月3日 · DC-SIGN, which is abundantly expressed by DC both in vitro and in vivo, mediates transient adhesion with T cells. Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC–T cell contact zone.