2024年12月24日 · DDIT3 (DNA Damage Inducible Transcript 3) is a Protein Coding gene. Diseases associated with DDIT3 include Myxoid Liposarcoma and Soft Tissue Sarcoma. Among its related pathways are Gene expression (Transcription) and Unfolded Protein Response (UPR).

DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. [5] [6] It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. [6]

该蛋白质通过与其他 C/EBP 成员 (如 C/EBP 和 LAP (肝激活蛋白) ) 形成异二聚体并阻止其 DNA 结合活性，从而发挥显性失活抑制剂的作用。 该蛋白质与脂肪生成和红细胞生成有关，被内质网应激激活，并促进细胞凋亡。 通过易位诱导该基因与 16 号染色体上的 FUS 或 22 号染色体上的 EWSR1 融合，在粘液样脂肪肉瘤或尤文肉瘤中产生嵌合蛋白。 已经鉴定出编码两种不同长度的亚型的多个选择性剪接的转录本变体。 [RefSeq 提供，2010 年 8 月] This gene encodes a …

DDIT3，即DNA损伤诱导转录本3，别名CHOP、GADD153，是一种转录因子，对细胞应激反应尤其是内质网应激具有关键调控作用。 它通过与ATF4相互作用，促进自噬相关基因表达，并通过抑制mTOR信号通路激活细胞自噬。 DDIT3还参与凋亡过程，通过调节Bcl-2家族和C/EBPδ诱导线粒体相关凋亡。 DDIT3在肿瘤细胞自噬与凋亡调控中扮演重要角色，其异常表达可能增加肿瘤细胞对治疗的敏感性，是肿瘤治疗的潜在靶点。 在谷氨酰胺饥饿条件下，DDIT3通过双重机制平衡糖 …

2024年3月20日 · DNA damage-inducible transcript 3 (DDIT3) gene, mapped to the human chromosome 12q13.3, encodes a protein that belongs to the CCAAT/enhancer-binding protein family of transcription factors. DDIT3 is involved in the proliferative control that responds to endoplasmic reticulum stress in normal conditions, dimerising other transcription factors ...

2024年10月3日 · DNA damage-inducible transcript 3 (DDIT3) is a well-known transcription factor that regulates the expression of apoptosis-related genes for promoting...

2022年12月9日 · Overexpression of DDIT3 in human healthy HSCs induces an MDS-like transcriptional state, and dyserythropoiesis, an effect associated with a failure in the activation of transcriptional programs...

2025年3月8日 · Transcription factor DDIT3 is a potential driver in pancreatic cancer. A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis. Deciphering the role of FUS::DDIT3 expression and tumor microenvironment in myxoid liposarcoma development.

2022年8月1日 · Recent studies have indicated that DDIT3/CHOP (a downstream transcription factor of ER stress) is an important effector in mediating ER stress to inhibit chondrogenesis. However, the underlying mechanism by which DDIT3 regulates chondrogenesis remains unclear.

内质网应激相关基因ddit3（也被称为chop）在这一过程中扮演了关键角色。ddit3作为一种转录因子，能够调控多种基因的表达，从而影响肿瘤细胞的自噬和凋亡。关于ddit3如何具体调控肿瘤细胞自噬与凋亡的分子机制仍不完全清楚。