2019年8月19日 · DFO was used to examine the role of iron in the contributions of FPN1 to cell growth and transformation. DFO reduced myeloma cell viability in a time-dependent manner, …

2018年5月29日 · Macrophages release iron into the bloodstream via a membrane-bound iron export protein, ferroportin (FPN). The hepatic iron-regulatory hormone hepcidin controls FPN …

Assessment of cytoplasmic hepcidin and ferroportin (FPN) protein levels in control and deferoxamine (DFO)-treated MCF-7 cells. A, Lysates of cells treated with 30, 100, or 300 µM …

2008年11月16日 · Fpn-mediated iron loss induces ferritin degradation by the proteosome. In this study we show that permeable iron chelators, desferirax or deferriprone also induce the …

2025年1月15日 · Our findings suggest that the downregulation of FPN may contribute to the pathogenesis of RA, indicating a potential role of iron dysregulation in this disease, and FPN …

2018年7月20日 · Fifty millimolar DFO also increased Fpn. Together, these data point towards a transcriptional induction of Fpn in response to changes in cellular iron levels. Epigenetic …

2022年8月2日 · To investigate the effect of iron deficiency on hepatocyte functions, human healthy hepatocytes were treated with deferoxamine (DFO, 100 μM) to remove ∼30% of their …

Nerve growth factor-beta (NGF-β)-differentiated PC12 cells, used as a model of neuronal cells, were evaluated in terms of their viability and expression of ferroportin after inducing cellular …

2018年3月21日 · With regard to FPN expression, it significantly increased in cells treated with 300 µM DFO for 24 hours and those treated with 30, 100, or 300 µM for 48 hours; untreated cells …

2022年3月22日 · In this study, we established a rat model of CKD by 5/6 nephrectomy, treated CKD rats with the ferroptosis inducer, cisplatin (CDDP), and the ferroptosis inhibitor, …