DHA appears to regulate the gene expression of cystathionine-γ-lyase, an enzyme that carries out transsulfuration of Hcy in a vitamin B6-dependent catalysis. Furthermore, DHA could up-regulate the synthesis of mRNA of 5-methyltetrahydrofolate reductase enzyme involved in the remethylation pathway to methionine [ 103 ].

将Hcy的功效与其他能够降低DHA的分子（还原型谷胱甘肽（GSH）和半胱氨酸（Cy））的功效进行了比较。 尽管所有三个分子均能够还原DHA，但GSH和Cy在低于100 micromol / l的浓度下无法将DHA还原为AA，而在200-300 micromol / l的浓度下只有不到5％的DHA被还原为AA。 相反，Hcy在低至10 micromol / l的浓度下将DHA化学计量地还原为AA。 在Jurkat和U937细胞中，细胞外Hcy浓度的增加抑制了细胞内脱氢抗坏血酸的摄取，表明细胞内Hcy降低DHA导致细胞 …

2001年2月16日 · To determine the reductive process of extracellular dehydroascorbic acid (DHA), molecules (homocysteine, homocysteine thiolactone, methionine, cysteine, and homoserine) were tested to identify those with the potential to reduce DHA to ascorbic acid (AA). Homocysteine (Hcy) was the most potent of the …

采用简易精神状况量表 (minimum mental state examination,MMSE)得分估测研究对象的认知功能,检测血清叶酸、Hcy、血浆DHA、外周血白细胞端粒长度以及线粒体拷贝数。 采用皮尔逊相关分析及Logistic回归分析,分析叶酸、Hcy、DHA、端粒长度以及线粒体拷贝数与认知功能及MCI的关系,以及它们之间的相互关系。 采用结构方程模型进行中介效应分析,评价端粒长度是否在叶酸或DHA与认知功能关系中发挥中介作用。 采用随机双盲对照试验,将招募的280例MCI老年人进行 …

2017年9月21日 · Hyperhomocysteinemia (HHcy) is a key risk factor in hepatic steatosis. In this study, we applied a metabolomic approach to investigate the changes in the metabolite profile due...

2001年2月16日 · To determine the reductive process of extracellular dehydroascorbic acid (DHA), molecules (homocysteine, homocysteine thiolactone, methionine, cysteine, and homoserine) were tested to identify those with the potential to reduce DHA to ascorbic acid (AA). Homocysteine (Hcy) was the most potent of the molecules tested.

2022年9月1日 · The findings on the effect of omega-3 supplementation on enzymes involved in the formation of homocysteine (Hcy) and the improvement of hyperhomocysteinemia are contradictory. The aim of this systematic and meta-analysis study was to investigate the effects of omega-3 supplementation on Hcy using existing randomized controlled trials (RCTs).

2001年3月1日 · To determine the reductive process of extracellular dehydroascorbic acid (DHA), molecules (homocysteine, homocysteine thiolactone, methionine, cysteine, and homoserine) were tested to identify...

Tomato juice enriched with n-3 (250 mg EPA+DHA) significantly reduced HCY (approximately 3 μM), after 2-weeks, as compared to tomato juice without n-3 for a small sample of healthy women; however, by the authors’ own admission, both juices provided antioxidant compounds such as phenolics and lycopene .

Hyperhomocysteinemia (HHcy) is a key risk factor in hepatic steatosis. In this study, we applied a metabolomic approach to investigate the changes in the metabolite profile due to HHcy-induced hepatic steatosis and the effects of omega-3 PUFA (polyunsaturated fatty …