We show that Dkk3 is upregulated in both hip and knee OA and in both synovial tissue and cartilage from diseased joints. Dkk3 upregulation is also reported in OA subchondral bone …

We provide evidence that Dkk3 is upregulated in OA and may have a protective effect on cartilage integrity by preventing proteoglycan loss and helping to restore OA-relevant signaling pathway …

2020年12月16日 · Dickkopf-related protein 3 (DKK3) is a secreted glycoprotein that has been implicated in the pathogenesis of a variety of diseases. Recent evidence suggests that urinary …

2024年12月24日 · DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3) is a Protein Coding gene. Diseases associated with DKK3 include Isolated Polycystic Liver Disease and Polycystic Liver …

2020年6月12日 · Dkk3 is a member of the Dickkopf family proteins, which are well-known Wnt signaling pathway inhibitors. We first tested the ability of Dkk3 to inhibit the canonical Wnt …

2018年5月1日 · Here we identified Dkk3 as the key secreted factor generated by muscles to induce sarcopenia and characterized the mechanism of Dkk3-dependent transcription …

Dkk3 expression is increased in OA but can be regulated IL1 and OSM. This suggests a balance of Dkk3 effects depending upon the biological stimuli within the cartilage. Dkk3 may act in a …

Dickkopf‑related protein 3 (DKK3) is an atypical member of the Wnt‑antagonistic dickkopf‑related protein (DKK) family. The availability of research into the role of DKK3 in the abnormal …

2019年2月28日 · To determine the role of a cytokine-like protein DKK3 (dikkopf-3) in directly transdifferentiating fibroblasts into endothelial cells (ECs) and the underlying mechanisms. …

2025年2月13日 · This review delves into the role of Dickkopf-3 (DKK3), a secreted glycoprotein and member of the Dickkopf family, in non-malignant diseases. DKK3 is particularly known for …