
Dimethyl Fumarate Induces Glutathione Recycling by
We previously demonstrated that DMF is capable of raising GSH levels even when glutathione synthesis is inhibited, suggesting enhanced GSH recycling. Here, we found that DMF indeed …
Dimethyl fumarate induces necroptosis in colon cancer cells through GSH ...
Key results: DMF but not MMF induced cell necroptosis, as demonstrated by the pharmacological tool necrostatin-1, transmission electron microscopy, LDH and HMGB1 release in CT26 cells. …
Dimethyl fumarate (富马酸二甲酯) - 仅供科研 | Nrf2 Activator
Dimethyl fumarate (DMF) 是一种具有口服活性且可透过血脑屏障的 Nrf2 激活剂,可诱导抗氧化剂基因表达上调。 Dimethyl fumarate 通过 GSH 耗竭/ ROS 升高/MAPKs 激活途径诱导结肠癌 …
Dimethyl Fumarate Reduces Methylglyoxal-derived Carbonyl
2024年11月22日 · Our findings indicate that DMF increases levels of glutathione (GSH), glutamate cysteine ligase modifier subunit (GCLM), and nuclear Nrf2 in SH-SY5Y cells. …
富马酸二甲酯通过GSH耗竭/ ROS增加/ MAPKs活化途径诱导结肠癌 …
通过与GSH和N-乙酰半胱氨酸(NAC)共同处理CT26细胞,可以抑制DMF诱导的细胞GSH水平降低以及细胞活力和活性氧(ROS)升高。 DMF激活CT26细胞中的JNK,p38和ERK …
Disrupting pro-survival and inflammatory pathways with dimethyl ...
2024年3月18日 · Dimethyl fumarate (DMF) is an anti-inflammatory and immunoregulatory drug used to treat patients with multiple sclerosis and psoriasis in which it blocks aberrant NF-κB …
Fumarate induces redox-dependent senescence by modifying
2015年1月23日 · Here, we show that the accumulation of fumarate caused by the inactivation of FH leads to oxidative stress that is mediated by the formation of succinicGSH, a covalent …
Dimethyl fumarate induces necroptosis in colon cancer cells through GSH ...
2015年5月8日 · We found that DMF but not MMF induced necroptosis in colon cancer cells by depleting cellular GSH and subsequently activating MAPKs. We propose that DMF has the …
Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 …
2021年9月9日 · In this study, we demonstrate a robust antilymphoma effect of DMF on both major DLBCL subtypes. DMF inhibited NF-κB and JAK/STAT3 survival signaling in ABC DLBCL, and …
Dimethyl Fumarate Reduces Methylglyoxal-derived Carbonyl
2024年11月22日 · Our findings indicate that DMF increases levels of glutathione (GSH), glutamate cysteine ligase modifier subunit (GCLM), and nuclear Nrf2 in SH-SY5Y cells. …