We previously demonstrated that DMF is capable of raising GSH levels even when glutathione synthesis is inhibited, suggesting enhanced GSH recycling. Here, we found that DMF indeed …

Key results: DMF but not MMF induced cell necroptosis, as demonstrated by the pharmacological tool necrostatin-1, transmission electron microscopy, LDH and HMGB1 release in CT26 cells. …

Dimethyl fumarate (DMF) 是一种具有口服活性且可透过血脑屏障的 Nrf2 激活剂，可诱导抗氧化剂基因表达上调。 Dimethyl fumarate 通过 GSH 耗竭/ ROS 升高/MAPKs 激活途径诱导结肠癌 …

2024年11月22日 · Our findings indicate that DMF increases levels of glutathione (GSH), glutamate cysteine ligase modifier subunit (GCLM), and nuclear Nrf2 in SH-SY5Y cells. …

通过与GSH和N-乙酰半胱氨酸（NAC）共同处理CT26细胞，可以抑制DMF诱导的细胞GSH水平降低以及细胞活力和活性氧（ROS）升高。 DMF激活CT26细胞中的JNK，p38和ERK …

2024年3月18日 · Dimethyl fumarate (DMF) is an anti-inflammatory and immunoregulatory drug used to treat patients with multiple sclerosis and psoriasis in which it blocks aberrant NF-κB …

2015年1月23日 · Here, we show that the accumulation of fumarate caused by the inactivation of FH leads to oxidative stress that is mediated by the formation of succinicGSH, a covalent …

2015年5月8日 · We found that DMF but not MMF induced necroptosis in colon cancer cells by depleting cellular GSH and subsequently activating MAPKs. We propose that DMF has the …

2021年9月9日 · In this study, we demonstrate a robust antilymphoma effect of DMF on both major DLBCL subtypes. DMF inhibited NF-κB and JAK/STAT3 survival signaling in ABC DLBCL, and …

2024年11月22日 · Our findings indicate that DMF increases levels of glutathione (GSH), glutamate cysteine ligase modifier subunit (GCLM), and nuclear Nrf2 in SH-SY5Y cells. …