Nature子刊：中山大学松阳洲团队发现DNA损伤修复通路的新选 …
DNA双链断裂（DNA double-strand break，DSB）是一种常见且高度有害的DNA损伤形式，严重威胁着基因组稳定性和细胞存活。 DSB修复缺陷或失调与肿瘤、衰老以及免疫缺陷等密切相关。
A dual role of Cohesin in DNA DSB repair - Nature
2025年1月20日 · Defects in repairing double-stranded breaks (DSBs) can lead to genomic instability, contributing to cancer, genetic disorders, immunological diseases, and …
DNA double-strand break–capturing nuclear envelope tubules drive DNA …
2024年4月17日 · DNA double-strand breaks (DSBs) are toxic lesions that can instigate aberrant chromosome rearrangements, stalling growth. Most DSBs are repaired by the evolutionarily …
Mechanism for local attenuation of DNA replication at double …
2025年2月19日 · Here we show that DSBs induce a local genome maintenance mechanism that inhibits replication initiation in DSB-containing topologically associating domains (TADs) …
DNA 损伤修复通路 | Cell Signaling Technology
dna 损伤的范围从单链断裂（ssb）和双链断裂（dsb）等磷酸二酯键断裂到包括嘧啶二聚体、错配和交联在内的碱基损伤都不同。 如果未正确修复损伤，则可能导致突变传播基因组不稳定 …
DNA损伤修复 - 知乎 - 知乎专栏
Ku蛋白（Ku70/Ku80）复合物识别结合到DSBs末端，Ku-DNA复合物招募DNA依赖蛋白激酶催化亚基（DNA-PKcs）激活其激酶活性，将自身磷酸化启动NHEJ通路，吸引重组酶Artemis加入 …
DNA double-strand break repair-pathway choice in somatic
In this Review, we consider DSB repair-pathway choice in somatic mammalian cells as a series of 'decision trees', and explore how defective pathway choice can lead to genomic instability. …
Nature | 刘丽萍/严振鑫等报导DNA断裂诱导修复的新机制 - 知乎
断裂诱导复制 （Break-induced replication ， BIR）是一种依赖 同源序列模板 进行DNA合成并修复的过程，专门修复单一末端的DNA双链断裂（one-ended DSB），比如破裂的 复制叉结构 …
Origin, Recognition, Signaling and Repair of DNA Double …
Achromosomal double-strand break (DSB) can arise from multiple sources including ionizing radiation and DNA replication itself. An understanding of the intricate pro tein pathways that …
Mapping the genetic landscape of DNA double-strand break repair
Cells repair DNA double-strand breaks (DSBs) through a complex set of pathways critical for maintaining genomic integrity. To systematically map these pathways, we developed a high …