2019年6月13日 · SAXS, coupled with size-exclusion chromatography (SEC-SAXS) and time-resolved (TR-SAXS) methods, is now providing high-resolution insight into macromolecular flexibility and ensembles, delineating biophysical landscapes, and facilitating high-throughput library screening to assess macromolecular properties and to create opportunities for drug ...

2022年9月27日 · Employing in situ small-angle X-ray scattering (SAXS), we show that addition of silica precursors induces substantial condensation of the DNA origami at early reaction times...

Small-angle x-ray scattering (SAXS) is uniquely sensitive to both the conformation and local environment (i.e. protein partner and associated ions) of the DNA. The primary challenge of studying multi-component systems with SAXS lies in resolving how each component contributes to the measured scattering.

2023年1月1日 · Small angle X-ray scattering (SAXS) offers a complementary method to NMR and X-ray crystallography that allows for low-resolution structural characterization of protein, DNA, and protein–DNA complexes in solution over a greater size range and irrespective of interdomain flexibility and/or disordered regions.

2024年11月27日 · We introduce an experimental pipeline for small-angle X-ray scattering (SAXS) to gather structural details about the solution-state NANPs assembled from up to 12 RNA strands. To the best of our knowledge, this study represents the largest multistranded RNA nanoassemblies characterized in this manner to date.

We show that SAXS data of gold-labeled samples significantly enhance the information content of SAXS measurements, allowing the unambiguous assignment of macromolecular sequence motifs to specific locations within a SAXS structure.

2018年5月29日 · 小角 X 射线散射 (SAXS) 提供了关于溶液中 DNA 纳米结构的整体平均状态的互补结构信息。 在这里，我们证明 SAXS 可以区分不同的单层 DNA 折纸瓦片，这些瓦片在固定在云母表面并用原子力显微镜成像时看起来相同。

Small angle X-ray scattering (SAXS) offers a complementary method to NMR and X-ray crystallography that allows for low-resolution structural characterization of protein, DNA, and protein-DNA complexes in solution over a greater size range and irrespective of interdomain flexibility and/or disordered regions.

Small angle X-ray scattering (SAXS) is a powerful method for investigating macromolecular structure in solution. SAXS data provide information about the size and shape of a molecule with a resolution of approximately 2–3 nm.

会成为针对因心血管疾病或衰老而患有心脏病的人的再生医学新策略。 研究小组使用了一种称为小角度X射线散射（SAXS）的技术，可揭示RNA分子的3-D包膜。 3.