Tat stands for "Trans-Activator of Transcription". The protein consists of between 86 and 101 amino acids depending on the subtype. [3] Tat vastly increases the level of transcription of the HIV dsDNA. Before Tat is present, a small number of RNA transcripts will be made, which allow the Tat protein to be produced.

摘要: 穿膜肽TAT 被证实可用于不同类型药物分子的递送, 包括核酸、蛋白质和小分子药物等。TAT可以通过共价连接和非共价连接等形式递送分子。但是迄今TAT采用非共价连接形式递送蛋白质分子的报道较少, 也未有研究比较过融合形式和非融合形式下TAT递送蛋白质 ...

2021年11月1日 · HIV-1 Tat uses different strategies to induce gene transcription. Tat binds with TAR hairpin to promote HIV-1 replication via p-TEFb recruitment. Tat also uses an alternative P-TEFb independent route to activate HIV-1 promoter using RelB. The macrophage resident un-integrated HIV-1 DNA is protected from undergoing latency by HIV-1 Tat.

1型 人免疫缺陷病毒转录激活因子TAT （human immunodeficiency virus-1 transcription activator， HIV-1 TAT）是第一个被发现的细胞穿透肽，它凭借一种无毒的、高效的方式进入细胞。 细胞穿透肽（cell penetrating peptides，CPPs）的一个重要特点是可以携带多种不同大小和性质的生物活性物质进入细胞，包括小分子化合物、染料、多肽、 多肽核酸 （peptide nucleo acid, PNA）、蛋白质、质粒DNA、siRNA、200nm的脂质体、噬菌体颗粒和超顺磁性粒子等，这一性质为其成为 …

Tat is a small, versatile, viral protein that controls transcription of the HIV genome, regulates cellular gene expression and generates a permissive environment for viral replication by altering the immune response and facilitating viral spread to multiple tissues.

Human immunodeficiency virus type 1 (HIV-1) encodes a transactivator of transcription (Tat) protein, which has several functions that promote viral replication, pathogenesis, and disease.

Thyroid hormone (T3) receptor alpha (T3Ralpha) binds to HIV-1 Tat, an interaction mediated through the DNA-binding domain of T3Ralpha (amino acids 51–118) and the arginine-rich basic region (amino acids 49–57) and possibly amino acids 58–72 of Tat

2025年2月4日 · 这项研究分析了Tat对Jurkat细胞中DNA甲基化和转录特征的影响。 用全长Tat（Tat101），Tat的第一个外显子（Tat72）或空载体转染细胞。 使用Infinium MethylationEPIC array评估DNA甲基化变化，并通过RNA-seq评估转录组改变。

1 天前 · The TAT peptide, derived from the HIV-1 trans-activator of transcription protein, has a distinct amino acid sequence that enables efficient cellular uptake. The most studied variant, TAT(48-60), consists of 13 amino acids: YGRKKRRQRRR. ... TAT also binds nucleic acids, particularly RNA and chromatin-associated DNA. Its arginine-rich sequence ...

2012年7月30日 · Genetic variation within tat of different HIV-1 subtypes has been shown to affect the interaction of the viral transactivator with cellular and/or viral proteins, influencing the overall level of transcriptional activation as well as its action as a neurotoxic protein.