CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1') [5] or DNAM-1 (DNAX Accessory Molecule-1) [5] is a ~65 kDa immunoglobulin-like …

dnam-1 是该家族中唯一的激活型受体分子。 因此，对 DNAM-1 与其配体的作用机制的研究，不仅能够阐明其激活 NK 细胞的作用机制，而且对以 DNAM-1 为靶点的免疫治疗性药物的开发具 …

The most famous member of this family, DNAX accessory molecule (DNAM-1, CD226), is an adhesion molecule that control NK cell cytotoxicity and interferon-γ production against a wide …

2019年1月3日 · 最近，PNAS (《美国科学院院报》)报道了中科院微生物所高福院士团队关于DNAM-1与配体CD155互作机制的重要研究成果。 研究团队解析了人DNAM-1和小鼠DNAM-1 …

2023年6月7日 · DNAM-1 is a major NK cell activating receptor and, together with NKG2D and NCRs, by binding specific ligands, strongly contributes to mediating the killing of tumor or virus …

2015年4月7日 · DNAM-1 + NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1 − NK cells …

参与识别和杀死病毒感染细胞的主要NK细胞激活受体是NKG2D和DNAM-1。 特别地，DNAM-1的配体是与允许病毒感染的机制有关的nectin / nectin样分子。 病毒采用几种免疫逃避策略，包 …

DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa includ- ing two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK …

2017年5月31日 · DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands …

2015年11月16日 · DNAM-1 (CD226) is an activating receptor expressed on natural killer (NK) cells, CD8 (+) T cells, and other immune cells. Upon recognition of its ligands, CD155 and …