2024年12月24日 · DNMT1 (DNA Methyltransferase 1) is a Protein Coding gene. Diseases associated with DNMT1 include Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant and Neuropathy, Hereditary Sensory, Type Ie .

DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is an enzyme that catalyzes the transfer of methyl groups to specific CpG sites in DNA, a process called DNA methylation. In humans, it is encoded by the DNMT1 gene. [5] Dnmt1 forms part of the family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B.

2023年2月7日 · 而DNMT1表达水平增加受肿瘤相关巨噬细胞（TAM）调控，DNMT1上调通过肿瘤抑制因子凝溶胶蛋白（Gelsolin）加重GC，而后者介导表观遗传抑制。 先前研究表明，由MHC（major histocompatibility complex）介导的抗原呈递是抗肿瘤免疫和对PD-1/PD-L1靶向治疗反应的重要修饰因子 ...

2022年11月21日 · Nature Communications - DNMT1 is an essential for maintaining genomic DNA methylation. Here, we report the cryo-EM structure of DNMT1 bound to ubiquitinated H3 and hemimethylated DNA,...

为了解决甲基化丢失的问题，DNMT1就派上了用场——DNMT1负责准确复制DNA甲基化形式，在DNA复制的过程中起着维持甲基化的作用（如下图所示）；而DNMT3a/3b的作用则是在原本任意一条DNA单链都不存在甲基化修饰的位点加上甲基化修饰，即从头（de novo）甲基化。

DNMT1 regulates miR-20a/TXNIP-mediated pyroptosis of retinal pigment epithelial cells through DNA methylation. DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells.

2012年2月16日 · DNMT1-related disorder is a degenerative disorder of the central and peripheral nervous systems comprising a phenotypic spectrum that includes hereditary sensory and autonomic neuropathy type 1E (HSAN1E) and autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCA-DN).

Nature|朱冰组首次在体内证实DNMT1可作为起始性DNA甲基转移酶，揭示卵子发生过程中DNA甲基化模式建立的机制—专家点评 BioArt生物艺术 科研等 2 个话题下的优秀答主

The DNMT1 gene provides instructions for making an enzyme called DNA methyltransferase 1. This enzyme is involved in DNA methylation, which is the addition of methyl groups, consisting of one carbon atom and three hydrogen atoms, to DNA molecules.

2025年2月9日 · BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...