Differential regulation of E2F1, DP1, and the E2F1/DP1 complex …
Coexpression of E2F1 and DP1 blocks ARF-induced relocalization of either subunit to the nucleolus. The E2F1/DP1 complex localizes in the nucleoplasm, whereas ARF is detected in …
The TFDP1 gene coding for DP1, the heterodimeric partner of the ...
2023年6月30日 · The TFDP1 gene codes for the heterodimeric partner DP1 of the transcription factor E2F. E2F, principal target of the tumor suppressor pRB, plays central roles in cell …
Differential requirement for dimerization partner DP between E2F …
2018年5月31日 · To determine the role of DP proteins in the induction of ARF gene expression and apoptosis by deregulated E2F, we established shRNA-mediated knockdown of DP1 …
The TFDP1 gene coding for DP1, the heterodimeric partner of the ...
2023年6月30日 · The TFDP1 gene codes for the heterodimeric partner DP1 of the transcription factor E2F. E2F, principal target of the tumor suppressor pRB, plays central roles in cell …
Differential requirement for dimerization partner DP between E2F ...
2018年5月31日 · The transcription factor E2F plays crucial roles in cell proliferation and tumor suppression by activating growth-related genes and pro-apoptotic tumor suppressor genes, …
High Conformational Flexibility of the E2F1/DP1/DNA Complex
2021年9月3日 · DP1 flexibility may be relevant for protein–protein and protein-DNA interactions. The E2F1 transcription factor is a master regulator of cell-cycle progression whose …
Dual functions of DP1 promote biphasic Wnt‐on and ... - The …
2012年7月6日 · DP1, a dimerization partner protein of the transcription factor E2F, is known to inhibit Wnt/β‐catenin signalling along with E2F, although the function of DP1 itself was not well …
Structure of the Rb C-Terminal Domain Bound to E2F1-DP1: A …
2005年12月16日 · Here we demonstrate a high-affinity interaction between RbC and E2F-DP heterodimers shared by all Rb and E2F family members. The crystal structure of an RbC-E2F1 …
转录因子 DP-1（TFDP1）基因 | MCE - MCE-生物活性分子大师
转录因子 dp-1： 该基因编码转录因子家族的一个成员，这些转录因子与 e2f 蛋白异二聚化以增强其 dna 结合活性并促进 e2f 靶基因的转录。 编码的蛋白质作为该复合物的一部分起作用，以 …
DP-1和E2F-1在细胞周期调节转录因子DRTF1 / E2F中的功能协同作 …
我们在这里报告说，DP-1和E2F-1存在于体内的DNA结合复合物中，它们作为E2F位点的异源二聚体有效且优先结合。 此外，对酵母和果蝇细胞的研究表明，DP-1和E2F-1在E2F位点依赖性转 …