Novel recombinational repair of a site-specific double-strand break (DSB) in a yeast chromosome was investigated. When the recognition site for the HO endonuclease enzyme is embedded in …

2005年11月17日 · In this strain, HO endonuclease introduces a DSB at MAT that can be repaired only by non-homologous end joining, although the principal proteins involved in homologous …

2020年10月14日 · DNA double-strand breaks (DSBs) are common genome lesions that threaten genome stability and cell survival. Cells use sophisticated repair machineries to detect and …

2023年2月12日 · In the 1950's the DSB (Danish State Railways) was looking for a diesel locomotive. It selected a series of 4 locomotives of type MY that were built by NOHAB in …

2021年11月8日 · Homologous recombination repairs DNA double-strand breaks (DSB) using an intact dsDNA molecule as a template. It entails a homology search step, carried out along a …

Yra1 overexpression was recently shown to promote accumulation of DNA:RNA hybrids favoring DNA double strand breaks (DSB), cell senescence and telomere shortening, via an unknown …

In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and …

DNA双链断裂（DNA double-strand break，DSB）是一种常见且高度有害的DNA损伤形式，严重威胁着基因组稳定性和细胞存活。 DSB修复缺陷或失调与肿瘤、衰老以及免疫缺陷等密切相关。

dna双链断裂是一种严重损伤，可引起缺失或染色体易位等突变。nhej和hr是dsb修复的两种主要方式，细胞需要选择针对特定情况的最佳修复途径。nhej在g1/s/g2期都可以起作用，而hr仅 …

在芽殖酵母中，一个问题是为什么 sc 组装最早在着丝粒区域启动，而启动重组的 dna 双链断裂 (dsb) 发生在整个基因组范围内。 我们将位点特异性 HO 核酸内切酶靶向酿酒酵母最长染色体上 …