Nucleolar DNA Double-Strand Break Responses Underpinning rDNA Genomic ...
2019年10月1日 · DNA double strand breaks (DSBs) are the most toxic form of DNA damage. To prevent damage accumulating, mammalian cells have evolved a complex network, collectively …
Nuclear and genome dynamics underlying DNA double-strand …
2025年3月17日 · In mammals, damaged rDNA is transcriptionally repressed by the kinase MST2 (STK3) and cohesin–human silencing hub (HUSH) complexes, thereby promoting DSB …
Pre-ribosomal RNA reorganizes DNA damage repair factors in …
2022年1月4日 · Here, by analyzing the localization of DSB repair factors in the XY body and DSB foci, we demonstrate that pre-ribosomal RNA (pre-rRNA) mediates the recruitment of DSB …
Nature文章：童明汉组合作实现在体外重构减数分裂DSB形成
2025年2月20日 · 该研究基于体外表达和纯化的小鼠 SPO11-TOP6BL 复合体，首次在体外成功重构了 DNA 双链断裂 (Double-Strand Break, DSB) 的形成，为解析减数分裂同源重组机制建立 …
Recent advances in the nucleolar responses to DNA double-strand …
2020年9月9日 · Recent discoveries have significantly extended our understanding of how cells respond to DNA double-strand breaks (DSBs) in the nucleolus, and new kinases and multiple …
Protection of repetitive DNA borders from self-induced meiotic ...
2011年8月7日 · DNA double strand breaks (DSBs) in repetitive sequences are a potent source of genomic instability, owing to the possibility of non-allelic homologous recombination (NAHR). …
ATM Dependent Silencing Links Nucleolar Chromatin …
2015年10月13日 · Resolution of DNA double-strand breaks (DSBs) is essential for the suppression of genome instability. DSB repair in transcriptionally active genomic regions …
修复核仁帽中的核糖体 DNA 断裂需要 RNA 聚合酶 II 介导的转录， …
高拷贝核糖体 DNA (rDNA) 基因由 RNA 聚合酶 I (RNAAPI) 高度转录，本质上不稳定，经常会因转录复制冲突而发生 DNA 双链断裂 (DSB)。 当 DSB 发生时，RNAPI 被 ATM 信号传导沉 …
新一代测序技术揭示了在内源DNA双链断裂中两种损伤诱导的RNA
2018年12月14日 · Our findings provide direct evidence for diRNA production at endogenous loci in mammalian cells and give insights into RNA processing at DSBs. 最近的研究表明，DNA双 …
A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA ...
2019年9月1日 · DNA double-strand breaks (DSBs) within rDNA induce both rDNA transcriptional repression and nucleolar segregation, but the link between the two events remains unclear. …