Dextran sodium sulfate (DSS) colitis is commonly used to study IBD, however, it is not considered the best model in which to study T cell involvement in intestinal disease. Our aim was to determine if antigen-specific T cells could be induced during DSS colitis and if they could be detected after disease resolution.

2015年3月25日 · We used the dextran sulfate sodium (DSS)-induced colitis model combined with gene-modified mice to monitor the progression of colitis, and simultaneously examine the number of Tregs and B...

2024年7月15日 · Lactobacillus paracasei r3 protects against dextran sulfate sodium (dss)-induced colitis in mice via regulating th17/treg cell balance

2016年2月1日 · We show that FXR activation by obeticholic acid (OCA) has systemic anti-inflammatory effects that include increased levels of plasma IL-10, inhibition of both DSS-colitis associated decrease in splenic dendritic cells (DCs) and increase in Tregs.

2020年12月1日 · Myeloid TL1A-Transgenic C57BL/6 mice and wild-type (WT) mice were administrated with dextran sulfate sodium (DSS) to explore the effects of TL1A in murine colitis. Bone marrow-derived DCs (BMDCs) were isolated to detect the ability of antigen phagocytosis and presentation.

Dextran sulfate sodium (DSS)-induced colitis is one of the most frequently used rodent models for inflammatory bowel disease (IBD). The aim of this study was to validate the murine DSS-induced colitis model using four therapeutic agents for IBD. C57BL/6 mice were exposed to 3% DSS for 5days followed …

To determine the STAT3 function of T cells in intestinal inflammation, we generated T cell-specific STAT3 knockout (KO) mice and used dextran sulfate sodium (DSS) to induce colitis. In this study, we demonstrated that T cell-specific STAT3 deletion alleviated DSS-induced colitis in mice, resulting in reduced histological scores and ...

1 天前 · The results showed a significant decrease in the proportion of CD3 + CD8 + T cells and an increase in the proportion of CD3 + CD4 + T cells in MLN from MS275-treated AOM-DSS tumors. The enhancement of immune suppression by MS275 and its contribution to tumor immune escape elucidate the diminished efficacy of MS275 in vivo relative to in vitro.

2013年7月25日 · Dextran sodium sulfate (DSS) colitis is commonly used to study IBD, however, it is not considered the best model in which to study T cell involvement in intestinal disease. Our aim was to determine if antigen-specific T cells could be induced during DSS colitis and if they could be detected after disease resolution.

Dextran sulfate sodium- (DSS-) induced chronic colitis is characterized by a predominant Th17/Th1-mediated immune response and mucosal inflammation which closely resembles important immunological aspects of CD [9–11]. IL-33, also known as interleukin-1 family member 11 (IL-1F11), was identified as a novel member of the IL-1 family.