2024年12月24日 · DUSP5 (Dual Specificity Phosphatase 5) is a Protein Coding gene. Diseases associated with DUSP5 include Epilepsy, Idiopathic Generalized 2 and Lymphoma, Mucosa-Associated Lymphoid Type. Among its related pathways are MAPK family signaling cascades and Signaling downstream of RAS mutants.

Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene. [5][6] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.

2017年12月11日 · Although dual-specificity phosphatase 5 (DUSP5), which inactivates extracellular signal-regulated kinase (ERK), suppresses tumors in several types of cancer, its functional roles...

该基因编码的蛋白质是双特异性蛋白磷酸酶亚家族的成员。 这些磷酸酶通过使磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基去磷酸化来灭活它们的靶激酶。 它们负向调节与细胞增殖和分化相关的丝裂原活化蛋白 (MAP) 激酶超家族成员 (MAPK/ERK、SAPK/JNK、p38) 。 双特异性磷酸酶家族的不同成员对各种 MAP 激酶表现出不同的底物特异性、不同的组织分布和亚细胞定位，以及细胞外刺激表达的不同诱导模式。 该基因产物使 ERK1 失活，在多种组织中表达，在胰腺和大脑中表达水 …

DUSP5 functions in the feedback inhibition of ERK1/2 signaling in response to TNFalpha, which resulted in increased inflammatory gene expression. Data show that dual specificity phosphatase 5 (DUSP5) is a downstream target of p68 RNA helicase (p68).

2017年11月5日 · 双特异性磷酸酶（dusps）通过去磷酸化灭活erk1/2并因此可以抑制炎性基因的表达。本研究中，研究人员发现dusp5，一种erk1/2磷酸酶，在饮食诱导的肥胖中在附睾白色脂肪组织（wat）中表达。此外，肥胖发展期间d

2024年12月10日 · Title: DUSP5 suppresses interleukin-1β-induced chondrocyte inflammation and ameliorates osteoarthritis in rats. Integrated analysis identifies DUSP5 as a novel prognostic indicator for thyroid follicular carcinoma.

2016年12月9日 · DUSP5 is a nuclear, inducible phosphatase with high affinity and fidelity for ERK1/2. By regulating the final step in the MAPK signaling cascade, DUSP5 exerts strong regulatory control over a central cellular pathway.

2003年8月28日 · Dual-specificity phosphatase 5 (DUSP5), a VH1-like enzyme that hydrolyses nuclear substrates phosphorylated on both tyrosine and serine/threonine residues, has a...

In this report, we show that TNFα-mediated phosphorylation of ERK1/2 and JNK stimulated expression of the ERK-specific phosphatase, dual-specificity phosphatase 5 (DUSP5) resulting in feedback inhibition of ERK signaling and ERK-dependent inflammatory gene …