Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene. [5][6][7] The protein encoded by this gene is a member of the dual specificity protein …

2024年12月24日 · DUSP6 (Dual Specificity Phosphatase 6) is a Protein Coding gene. Diseases associated with DUSP6 include Hypogonadotropic Hypogonadism 19 With Or Without …

Dual-specificity phosphatase 6 (DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback …

Dual-specificity phosphatase 6 (DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback …

DUSP6 plays a role as a tumor suppressor through dephosphorylation of p38, JNK and ERK (14), which are the major molecules in the MAPK signaling pathway. Activation of ERKs in cancer …

DUSP6 regulates radiosensitivity in glioblastoma by modulating the recruitment of phosphorylated DNAPKcs at DNA double-strand breaks. DUSP6 expression is associated with osteoporosis …

2020年3月25日 · Here, we show that dual-specificity phosphatase 6 (DUSP6) dephosphorylates Drp1-S616 independently of its known substrates ERK1/2. DUSP6 keeps Drp1-S616 …

The allosteric DUSP6 inhibitor BCI restores full responsiveness to TCR stimulation, suggesting that DUSP6 could be a promising target for improving cellular immune responses to …

Dual-specificity phosphatase 6 (DUSP6), a specific negative feedback regulator of phosphorylated extracellular signal-regulated kinase, was found to play an important role in numerous types of …

2025年1月4日 · Transcriptomic analyses demonstrate that DUSP6 is markedly overexpressed in PDAC tumors compared to non-tumoral pancreatic tissue. Single-cell RNA-seq reveals its …