Double homeobox, 4 also known as DUX4 is a protein which in humans is encoded by the DUX4 gene. [3] Its misexpression is the cause of facioscapulohumeral muscular dystrophy (FSHD).

2024年12月24日 · DUX4 (Double Homeobox 4) is a Protein Coding gene. Diseases associated with DUX4 include Facioscapulohumeral Muscular Dystrophy 1 and Soft Tissue Sarcoma. …

双同源异型框4 （英語： Double homeobox, 4，简称DUX4）基因位于 染色体 4q35亚端粒区域的D4Z4重复序列。 D4Z4重复序列的长度具多态性，在第10号染色体也发现类似D4Z4重复序列 …

Double homeobox 4 (DUX4) encodes for a transcription factor with increasingly important roles in normal physiology and in disease. During the early steps of embryogenesis, DUX4 is involved …

2020年9月7日 · DUX4 is a highly regulated transcription factor and its expression in skeletal muscle contributes to multiple cellular toxicities and pathologies ultimately leading to muscle …

2022年3月22日 · Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos. Here we show that induced human DUX4 expression substantially alters the …

2022年5月1日 · Double homeobox 4 (DUX4) is an early embryonic transcription factor whose expression in the skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). …

Targeting DUX4-mediated toxicity in skeletal muscle was achieved by (1) genetically or epigenetically regulating DUX4 expression, (2) directly targeting DUX4 transcript by RNAi or …

Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos. Here we show that induced human DUX4 expression substantially alters the chromatin …

2017年5月1日 · Here, we present multiple lines of evidence that a eutherian-specific multicopy retrogene, DUX4, encodes a transcription factor that activates hundreds of endogenous genes …