Protein kinase C - Wikipedia
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
第二节 蛋白激酶C的信号传导通路和作用 - KKME
PKC信号通道是一条重要的细胞内信息传递通道，它存在于多种细胞内，通过催化蛋白质磷酸化反应、影响受体的上下调节、细胞膜和骨架的重塑及对转录的正负调节来调整细胞内某些特定的过程，而将各种有关的细胞膜外的生物信息在细胞膜内传递下去，从而对细胞的增殖、分化、凋亡、转录、致癌性、细胞毒效应以及细胞迁移等多种生理活动产生调控作用。 许多细胞可以表达多种PKC的亚型，而每一种亚型又可以引起细胞产生不同的作用。 对所有的PKC来说，通过细胞 …
蛋白激酶C - 百度百科
乙酸 豆塞外 佛波酯 （12-o-tertradecanoylphordol-13-acetate, TPA;或phorbol-12-myristate-13-acetate,PMA）是一种促 肿瘤 剂，由于基结构与DAG相似，可在很低浓度下模拟DAG，活化PKC，使PKC亲和力增至10-7M。PKC是TPA的受体，当TPA插入细胞膜后可以替代DAG而直接活 …
Diacylglycerol-evoked activation of PKC and PKD isoforms in …
2020年5月28日 · Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated ...
壹生资讯-糖尿病大血管病变发病机制——蛋白激酶C（PKC）途径
2021年1月31日 · dag是机体内主要的pkc激动剂。生理情况下，dag主要来源于磷酸肌醇的代谢和磷脂酰胆碱的裂解，但也可由脂质 前体 在磷脂酶a2的作用下释放出游离脂肪酸而生成。高血糖激活pkc信号通路主要通过dag途径。
PKC 通路 | Cell Signaling Technology
蛋白激酶 c (pkc) 家族成员调控大量的细胞反应，包括基因表达、蛋白分泌、细胞增殖和炎性反应。其基本的蛋白结构包括一个 n 端调节区，该调节区由一个铰链区连接至 c 端激酶区域。
PKD at the crossroads of DAG and PKC signaling - PubMed
DAG regulates the intracellular localization of PKD and also activates PKD through PKC by phosphorylation. The PKC-PKD signaling cascade is crucial to PKD function in cells. Important discoveries have been made regarding the roles of PKD in cell growth, gene expression, survival, motility, protein trafficking and lymphocyte biology.
Protein kinase C and beyond - Nature Immunology
2004年7月28日 · DAG binds to conserved C1 domains in many different molecules, including various isoforms of PKC, PKD, Ras-GRP (activators of the GTPase Ras) and DGK (which phosphorylates DAG to produce ...
Structural anatomy of Protein Kinase C C1 domain interactions …
2022年5月16日 · PKCs define a central DAG-sensing node in intracellular phosphoinositide signaling pathways that regulate cell growth, differentiation, apoptosis, and motility 9. Shortly after their discovery,...
PKD at the crossroads of DAG and PKC signaling - ScienceDirect
2006年6月1日 · Protein kinase D (PKD), a novel DAG receptor, has been the subject of intense investigation in recent years. DAG regulates the intracellular localization of PKD and also activates PKD through PKC by phosphorylation. The PKC–PKD signaling cascade is crucial to PKD function in cells.