2024年12月24日 · DBF4 (DBF4-CDC7 Kinase Regulatory Subunit) is a Protein Coding gene. Diseases associated with DBF4 include Ataxia-Telangiectasia and Meier-Gorlin Syndrome 1 . Among its related pathways are Activation of the pre-replicative complex and Mitotic G1 phase and G1/S transition .

Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans. [5][6][7] DBF4 has been shown to interact with: ORC6L. [8] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. ^ "Mouse PubMed Reference:".

2024年8月8日 · In human cells, the S-phase-promoting kinase CDC7 exists in two alternative complexes: CDC7-DBF4 or CDC7-DRF1. Here, Göder et al. show that while CDC7’s essential function can be supported by both subunits, DBF4 is the primary mediator of CDC7 activity during DNA replication.

2024年4月3日 · Here, we identify Dbf4-dependent kinase (DDK) as a second major cell cycle regulator of DNA end resection. Using inducible genetic and chemical inhibition of DDK in budding yeast and human cells,...

2022年5月25日 · When Dbf4 is bound to Cdc7 the resulting complex is referred to as Dbf4-dependent Cdc7 kinase (DDK). The complex is regulated through Dbf4, as Dbf4 protein stability is strictly cell cycle...

2013年4月4日 · Dbf4 (Dumbbell former 4 protein) is the regulatory subunit of the Cdc7 kinase which plays critical roles in DNA replication, 1 activation of the replication checkpoint, 2 meiosis, 3 translesion synthesis, 4 histone homeostasis, 5 and mitotic exit. 6 Levels of Cdc7 are constant throughout the cell cycle, however it only becomes functional when ...

Dbf4-Dependent Kinase (DDK) has a well-established essential role at origins of DNA replication, where it phosphorylates and activates the replicative MCM helicase. It also acts in the response to mutagens and in DNA repair as well as in key steps ...

Dbf4 is the activation subunit for Cdc7, a conserved kinase essential for initiation of DNA replication. Dbf4 is evolutionally conserved and carries three conserved motifs, motif-N, -M and, -C. Motif-M or -C interacts with Cdc7 on its own, but motif-M …

2012年1月1日 · We demonstrated that ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) proteins directly phosphorylate Dbf4 in response to ionizing radiation and replication stress.

2024年3月29日 · dbf4依赖性激酶（ddk）是由dbf4与cdc7结合形成，可激活解螺旋酶，在细胞的复制中发挥重要作用。 DBF4作为调节亚基，还可以通过与其他蛋白结合，直接或间接地激活细胞周期激酶，进一步调节细胞周期。