mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene. [5] Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme.

2024年12月24日 · DCP1A (Decapping MRNA 1A) is a Protein Coding gene. Diseases associated with DCP1A include Schinzel-Giedion Midface Retraction Syndrome and Metaphyseal Chondrodysplasia, Schmid Type. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Peptide chain elongation.

2020年8月17日 · We identify messenger RNA-decapping enzyme 1A (DCP1A) as a key regulator of Tsix, a noncoding RNA implicated in allelic choice through X-chromosome pairing. DCP1A controls Tsix half-life and...

2024年12月24日 · Dephosphorylation of DCP1A S563 facilitates both self-renewal and differentiation of ESCs through promoting P body formation and RNA storage. In summary, our study identified 66 MEK substrates supporting the extracellular signal-regulated kinase (ERK)-independent function of MEK and revealed that DCP1A, phosphorylated by …

2024年12月24日 · In summary, our study identified 66 MEK substrates supporting the extracellular signal-regulated kinase (ERK)-independent function of MEK and revealed that DCP1A, phosphorylated by MEK, regulates ESC self-renewal and differentiation through modulating P body formation.

DCP1a 和 DCP1b 是主要 mRNA 帽水解酶 DCP2 的旁系同源辅因子蛋白。 由于低等真核生物只有一个 DCP1 辅因子，这种进化分歧所带来的功能优势仍不清楚。 在这里，我们报告了 DCP1a 和 DCP1b 的首次功能解剖，证明 DCP1a 和 DCP1b 是脱帽酶 DCP2 的独特的非冗余辅因子，在脱帽复杂的完整性和特异性方面具有独特的作用。 具体而言，DCP1a 对于脱帽复合物组装以及脱帽复合物与 mRNA 帽结合蛋白之间的相互作用至关重要。 相比之下，DCP1b 对于揭开与翻译机 …

2024年2月5日 · Our results highlight the importance of human DCP1 in decapping process and show that the EVH1 domain of DCP1 enhances the mRNA-binding affinity of DCP2. Transcriptome and metabolome analyses outline the distinct functions of DCP1a and DCP1b in human cells, regulating specific endogenous mRNA targets and biological processes.

2025年2月9日 · DCP1A is an unfavorable prognostic-related enhancer RNA in hepatocellular carcinoma. Expression of DCP1a in gastric cancer and its biological function and mechanism in chemotherapy resistance in gastric cancer cells. Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover.

这种蛋白质和另一种脱帽酶形成脱帽复合物，它与无义介导的衰变因子 hUpf1 相互作用，并可能被募集到含有过早终止密码子的 mRNA 中。 该蛋白还参与 TGF-β 信号通路。 该基因的可变剪接导致多个转录变体。 [RefSeq 提供，2014 年 2 月] Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping Enzyme.

2025年2月8日 · ERK-phosphorylated Dcp1a enhances its interaction with the decapping enzyme Dcp2 during early differentiation of 3T3-L1 cells. Recruitment of DCP1A and DCP2 increases the mRNA degradation capacity of the maturing oocyte so that by the 2-cell stage, most of the maternal mRNA is degraded.