2023年11月22日 · Damage-specific DNA binding protein 1 (DDB1) is a component of the Cullin4A/B-RING E3 ubiquitin ligase (CRL4) complex and functions as an adaptor protein between Cullin4A/B (CUL4A/B) and...

DDB1 contains 1140 amino acids, amounting to a mass of 127 kDa. [8] As its name suggests, DDB1 was initially implicated in the process of a specific type of DNA repair known as nucleotide excision repair.

2011年12月1日 · DDB1 interacts with the Fmod and MMP-13 promoters and may function as a transcriptional partner of E2F1. DDB1 targets the replication licensing protein (Cdt1) for ubiquitination to prevent the replication of damaged DNA. DDB1 in cell cycle regulation and DNA repair: molecular mechanisms that modulate the p2 Kip1 levels after DNA

The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in …

2024年12月24日 · DDB1 (Damage Specific DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with DDB1 include White-Kernohan Syndrome and Xeroderma Pigmentosum, Complementation Group E. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA repair pathways, full network.

Damage-specific DNA binding protein 1 (DDB1) is a multifunctional protein that was first isolated as a subunit of a heterodimeric complex that recognises the UV-induced DNA lesions in the nucleotide excision repair pathway. DDB1 and DDB2 form a complex that promotes the global genome repair (GG-NER) …

The DDB1 gene encodes damage-specific DNA-binding protein 1, which plays a vital role in the DNA damage response, specifically in the nucleotide excision repair pathway where it functions as part of the CUL4-DDB1 ubiquitin E3 ligase complex (CRL4).

由该基因编码的蛋白质是异二聚体 DNA 损伤结合 (DDB) 复合物的大亚基 (p127) ，而另一种蛋白质 (p48) 形成小亚基。 这种蛋白质复合物在核苷酸切除修复中起作用，并在紫外线损伤后与 DNA 结合。 这种复合物的活性缺陷导致着色性干皮病互补组 E (XPE) 患者的修复缺陷 - 一种常染色体隐性遗传病，其特征是光敏性和癌症早发。 然而，仍有待突变分析来证明 XPE 患者的缺陷是在该基因中还是在编码小亚基的基因中。 此外，Best vitelliform mascular dystrophy 在 11q 上被映射 …

2014年7月16日 · IMiDs target the E3 ubiquitin ligase CUL4–RBX1–DDB1–CRBN (known as CRL4 CRBN) and promote the ubiquitination of the IKAROS family transcription factors IKZF1 and IKZF3 by CRL4 CRBN. Here we...

DDB1 (Damage-specific DNA binding protein 1) 是一种多功能蛋白，最早是作为紫外诱导复合物（与DDB2形成异源二聚体）中的一个组分被发现的。 目前，DDB1被广泛认为是Cullin 4（CUL4）泛素连接酶复合物的重要架构蛋白, 通过含有WD40结构域的蛋白作为适配器来识别并泛 …